Between the primate and 'reptilian' brain: Rodent models demonstrate the role of corticostriatal circuits in decision making.
Between the primate and 'reptilian' brain: Rodent models demonstrate the role of corticostriatal circuits in decision making.
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DOI：
10.1016/j.neuroscience.2014.12.042
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发表时间：
2015-06-18
期刊：
影响因子：
3.3
通讯作者：
Wilbrecht L
中科院分区：
文献类型：
--
作者：
Lee AM;Tai LH;Zador A;Wilbrecht L
决策可以被定义为将来自外部世界的信息灵活地整合和转化为行动。近年来，新的遗传工具和新的行为模式的发展使得研究啮齿动物的各种行为变得非常有吸引力。从某些角度来看，啮齿类动物不是一个可接受的模型，因为与非人类灵长类动物相比，啮齿类动物的行为更简单，这通常归因于它们的皮质发育不太广泛。我们认为，决策可以接近跨物种的共同框架。我们回顾了比较解剖学的见解，这表明皮质-纹状体连接的扩展是行为灵活性进化增加的关键发展。我们简要回顾了研究，建立了一个角色，皮质纹状体电路在综合决策。最后，我们提供了一个概述最近，高度互补的啮齿动物决策研究使用遗传工具，揭示了新的细胞和时间分辨率如何，何时何地信息可以集成和比较纹状体电路影响选择。
Decision making can be defined as the flexible integration and transformation of information from the external world into action. Recently, the development of novel genetic tools and new behavioral paradigms has made it attractive to study behavior of all kinds in rodents. By some perspectives, rodents are not an acceptable model for the study of decision making due to their simpler behavior often attributed to their less extensive cortical development when compared to non-human primates. We argue that decision making can be approached with a common framework across species. We review insights from comparative anatomy that suggest the expansion of cortical-striatal connectivity is a key development in evolutionary increases in behavioral flexibility. We briefly review studies that establish a role for corticostriatal circuits in integrative decision making. Finally, we provide an overview of a few recent, highly complementary rodent decision making studies using genetic tools, revealing with new cellular and temporal resolution how, when and where information can be integrated and compared in striatal circuits to influence choice.