Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target.
Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target.
复制标题
DOI：
10.1155/jbb/2006/31825
复制
发表时间：
2006
影响因子：
--
通讯作者：
Iqbal K
中科院分区：
文献类型：
--
作者：
Gong CX;Liu F;Grundke-Iqbal I;Iqbal K
近二十年来的研究为阿尔茨海默病（AD）的分子机制提供了新的见解。AD研究中的里程碑式发现之一是证明了以tau病理学为特征的神经元变性是AD和其他tau病变的发病机制的核心，并且tau的异常过度磷酸化是神经元变性的关键。本文综述了tau蛋白的病理学及其磷酸化/去磷酸化系统的研究进展。还提出了神经元变性机制的最新模型，并讨论了通过纠正蛋白磷酸化/去磷酸化的失调来治疗AD的有希望的治疗靶点。
Studies during the last two decades have provided new insights into the molecular mechanism of Alzheimer's disease (AD). One of the milestone findings in AD research was the demonstration that neurofibrillary degeneration characterized by tau pathology is central to the pathogenesis of AD and other tauopathies and that abnormal hyperphosphorylation of tau is pivotal to neurofibrillary degeneration. This article reviews the recent research advances in tau pathology and the underlying dysregulation of the protein phosphorylation/dephosphorylation system. An updated model of the mechanism of neurofibrillary degeneration is also presented, and a promising therapeutic target to treat AD by correcting dysregulation of protein phosphorylation/dephosphorylation is discussed.