Hemagglutinin variants of reovirus type 3 have altered central nervous system tropism.
Hemagglutinin variants of reovirus type 3 have altered central nervous system tropism.
复制标题
3 型呼肠孤病毒的血凝素变种改变了中枢神经系统的趋向性。
DOI：
10.1126/science.6301010
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Fields,BN
中科院分区：
文献类型：
--
作者：
Spriggs,DR;Bronson,RT;Fields,BN
Variants of the Dearing strain of reovirus type 3 with antigenically altered hemagglutinin proteins are much less neurovirulent than the parental virus. When injected intracerebrally into mice these variants infected a subset of the brain neurons that were infected by the parental virus. When injected intraperitoneally, the variants did not spread to the brain. These results indicate that minor modifications of the reovirus hemagglutinin dramatically alter the ability of the virus to spread into and injure the central nervous system.
