Effect of Helicobacter pylori Eradication on Insulin Resistance, Serum Lipids and Low-Grade Inflammation
Effect of Helicobacter pylori Eradication on Insulin Resistance, Serum Lipids and Low-Grade Inflammation
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DOI：
10.1097/smj.0b013e3181cf373f
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发表时间：
2010-03-01
影响因子：
1.1
通讯作者：
Ataseven, Hilmi
中科院分区：
文献类型：
--
作者：
Gen, Ramazan;Demir, Mehmet;Ataseven, Hilmi
背景/目的：许多研究表明幽门螺杆菌（HP）感染与胰岛素抵抗密切相关。本研究旨在探讨HP根除对胰岛素抵抗、血脂和低度炎症的影响。材料和方法：这是一项前瞻性、开放标签、单中心研究，包括159例患者。HP感染患者接受14天的顺序治疗。采用HOMA-IR（胰岛素抵抗稳态模型评估）水平评估胰岛素抵抗。结果：研究了88例HP感染患者和71例未感染患者。HP感染患者HOMA-IR、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、C反应蛋白（CRP）水平显著高于未感染HP的患者，HDL-C水平显著低于未感染HP的患者（P < 0.05）。顺序方案对消化不良患者的HP根除率为53.4%。根治结束6周后，根治成功患者的平均空腹胰岛素、HOMA-IR、TC、TG、LDL-C、CRP水平较治疗前显著降低（P < 0.05）， HDL-C水平较治疗前显著升高（P < 0.05）。根除不成功患者的平均空腹胰岛素、HOMA-IR、TC、TG、LDL-C、CRP、HDL-C水平与治疗前相比无显著差异（P < 0.05）。结论：本研究显示HP根除对胰岛素抵抗、动脉粥样硬化性脂质异常和低度炎症的有益作用。结果表明，根除HP可预防冠状动脉疾病和代谢综合征。
Background/Aim: Many studies have revealed a close relationship between Helicobacter pylori (HP) infection and insulin resistance. The aim of this study was to investigate the effects of HP eradication on insulin resistance, serum lipids and low-grade inflammation.Materials and Methods: This was a prospective, open-label, single-center study which consisted of 159 patients. The patients with HP infection received a 14-day sequential regimen. A HOMA-IR (homeostasis model assessment of insulin resistance) level was used to assess insulin resistance.Results: Eighty-eight patients with HP infection and seventy-one patients without HP infection were studied. HOMA-IR, total cholesterol (TC), triglyceride (TG), LDL cholesterol (LDL-C) and C reactive protein (CRP) levels were significantly higher and HDL-cholesterol (HDL-C) levels were significantly lower in patients with HP infection compared to the patients without HP infection (P < 0.05). The HP eradication rates with a sequential regimen in dyspeptic patients were 53.4%. Six weeks after the end of eradication therapy, the mean fasting insulin, HOMA-IR, TC, TG, LDL-C, and CRP levels in patients with successful eradication were significantly decreased from the pretreatment levels (P < 0.05) and HDL-C level was significantly increased from the pretreatment levels (P < 0.05). The mean fasting insulin, HOMA-IR, TC, TG, LDL-C, CRP levels and HDL-C levels in patients with unsuccessful eradication were not significantly changed from pretreatment levels (P < 0.05).Conclusion: This study showed beneficial effects of HP eradication on insulin resistance, atherogenic lipid abnormalities and low-grade inflammation. The results suggest that HP eradication may prevent coronary artery disease and metabolic syndrome.