The evolution of noncoding DNA: how much junk, how much func?
The evolution of noncoding DNA: how much junk, how much func?
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DOI：
10.1016/j.tig.2005.08.001
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发表时间：
2005-10-01
影响因子：
11.4
通讯作者：
Castillo-Davis, CI
中科院分区：
文献类型：
--
作者：
Castillo-Davis, CI
基因组规模的比较序列分析打开了大门，系统分析的顺式作用的调控DNA。现在我们可以开始回答一些基本的问题，比如，基因组中有多少有意义的非编码序列？不同物种中功能性非编码序列的自然选择有多强？最近的两篇文章利用比较基因组学方法，试图以令人惊讶的结果回答这些问题。
Comparative sequence analysis on a genomic scale has opened the door for the systematic analysis of cis-acting regulatory DNA. It is now possible to begin to answer basic questions such as, how much meaningful noncoding sequence is in the genome? How strong is natural selection on functional noncoding sequences in different species? Two recent articles have capitalized on the comparative genomic approach in an attempt to answer these questions with surprising results.