Measures to prevent transfusion-associated protozoal infections in non-endemic countries.
Measures to prevent transfusion-associated protozoal infections in non-endemic countries.
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DOI：
10.1016/j.tmaid.2006.01.010
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发表时间：
2007-03-01
影响因子：
12
通讯作者：
Lefrere, J-J
中科院分区：
文献类型：
--
作者：
Garraud, O;Andreu, G;Lefrere, J-J
了解原虫通过血液传播的风险至关重要，因为：(i) 世界已经全球化，旅行频繁，移民增加； (ii) 血源性原生动物在热带地区很常见； (iii) 原生动物发展出逃避宿主免疫系统的生物手段，以及复杂的检测、监视和生物测试； (iv) 治疗或预防不足以控制危及生命的寄生虫。这个问题与法国相关，因为该国的非大陆领土，例如位于亚马逊盆地的法属圭亚那，是各种疟原虫亚种的地方病。导致疟疾和导致恰加斯病的克氏锥虫。在法国，尽管过去三十年来人口迁移有所增加，但对献血者的具体询问仍然是随意的：必须强调具体询问，并应识别“有风险”的献血者并随后将其排除在献血之外。仅排除献血者只能部分有效，还需要对献血进行相关的生物学测试，特别是通过 CE 标记的测试对克氏锥虫进行测试，以组织一致的预防政策：因此，精确的研究将确定哪些献血需要接受这项额外的合格测试（如果有）。
To understand the risk of protozoa transmission by blood is critical as: (i) the world has become globalized with extensive travel, and increased immigration; (ii) blood-borne protozoa is common in inter-Tropical areas; (iii) protozoa develop biological means to escape hosts' immune systems, together with complicated detection, surveillance, and biological testing; and (iv) life threatening-parasites are inadequately controlled by treatment or prevention. This question is relevant in France, with it's non-continental territories, such as French Guiana, located in the Amazon Basin, which is endemic for various Plasmodium ssp. responsible for malaria, and for Trypanosoma cruzi, which is responsible for Chagas disease. In France, specific questioning of blood donors is haphazard despite the increase in population migration over the last three decades: specific questioning must be emphasized and 'at-risk' donors should be identified and subsequently excluded from donation. Donor exclusion alone would only be partially efficient, there is also a need for relevant biological testing of blood donations and in particular for T. cruzi through the CE-marked test to organize a coherent prevention policy: precise studies would thus define which blood donations are subjected to this additional qualifying test when available.