Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis
Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis
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DOI：
10.1016/j.matbio.2017.10.004
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发表时间：
2019-01-01
期刊：
影响因子：
6.9
通讯作者：
Kletsas, Dimitris
中科院分区：
文献类型：
--
作者：
Mavrogonatou, Eleni;Pratsinis, Harris;Kletsas, Dimitris
正常细胞经过一定数量的连续分裂或暴露于基因毒性应激后，开始衰老，其特征是永久的生长停滞。此外，它们分泌的促炎和分解代谢介质水平增加，统称为“衰老相关分泌表型”。此外，衰老细胞表现出许多细胞外基质成分的表达和组织改变，导致其微环境的特异性重塑。在这篇综述中，我们介绍了与细胞衰老相关的细胞外基质改变的最新知识，并批判性地讨论了某些典型的例子，强调了衰老细胞在正常和病理条件下各种组织稳态中的模糊作用。(C) 2017 Elsevier B.V.版权所有
Normal cells after a defined number of successive divisions or after exposure to genotoxic stresses are becoming senescent, characterized by a permanent growth arrest. In addition, they secrete increased levels of pro-inflammatory and catabolic mediators, collectively termed "senescence-associated secretory phenotype". Furthermore, senescent cells exhibit an altered expression and organization of many extracellular matrix components, leading to specific remodeling of their microenvironment. In this review we present the current knowledge on extracellular matrix alterations associated with cellular senescence and critically discuss certain characteristic examples, highlighting the ambiguous role of senescent cells in the homeostasis of various tissues under both normal and pathologic conditions. (C) 2017 Elsevier B.V. All rights reserved.