Transmission of Streptococcus pneumoniae in Rural Gambian Villages: A Longitudinal Study
Transmission of Streptococcus pneumoniae in Rural Gambian Villages: A Longitudinal Study
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DOI：
10.1086/652443
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发表时间：
2010-06-01
影响因子：
11.8
通讯作者：
Adegbola, Richard A.
中科院分区：
文献类型：
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作者：
Hill, Philip C.;Townend, John;Adegbola, Richard A.
背景。为了准备在全国范围内引入限价肺炎球菌疫苗，我们研究了肺炎链球菌的鼻咽携带模式及其在冈比亚村庄随时间的传播情况。方法。我们在一年多的时间里，每两周采集 2 个村庄 19 户 158 名村民的鼻咽拭子标本。我们研究了肺炎链球菌携带的患病率和持续时间、家庭规模和组成对携带的影响，以及家庭内部和之间的序列类型特异性携带。结果。 97% 的儿童和 85% 的成人在某个时候携带肺炎链球菌。 1522 个分离株中有 53 种血清型。对于所研究的所有血清型（9V 除外），儿童携带病毒的情况比成人更常见。随着年龄的增加，携带时间总体呈缩短趋势（P = .043），并且不同血清型之间的携带持续时间存在显着差异。对于大多数血清型来说，如果家庭中有其他携带者，成为携带者的可能性就更大。携带率因血清型而异。最值得注意的是，血清型 5 携带仅发生在 1 个村庄，并且是暂时性的。来自 1 个村庄的 6B 血清型分离株的多位点序列分型揭示了 8 种不同的序列类型，并有力地证明了家庭之间非随机分布（P
Background. To prepare for national introduction of a pneumococcal vaccine of restricted valency, we studied the pattern of nasopharyngeal carriage of Streptococcus pneumoniae and its transmission in Gambian villages over time.Methods. We collected nasopharyngeal swab specimens every 2 weeks from 158 villagers in 19 households in 2 villages over 1 year. We studied the prevalence and duration of S. pneumoniae carriage, the effect of household size and composition on carriage, and sequence type-specific carriage within and between households.Results. Ninety-seven percent of children and 85% of adults carried S. pneumoniae at some time. Fifty-three serotypes were represented among 1522 isolates. Carriage was more common among children than adults for all serotypes studied except 9V. There was an overall trend toward shorter carriage with increasing age (P = .043) and significant differences in carriage duration between serotypes. For most serotypes, the odds of being a carrier were greater if there were other carriers in the household. The prevalence of carriage varied by serotype. Most notably, serotype 5 carriage occurred in only 1 village and was transient. Multilocus sequence typing of serotype 6B isolates from 1 village revealed 8 different sequence types and strong evidence of nonrandom distribution among households (P