Intimal medial thickness of the carotid artery in South Indian diabetic and non-diabetic subjects: the Chennai Urban Population Study (CUPS)
Intimal medial thickness of the carotid artery in South Indian diabetic and non-diabetic subjects: the Chennai Urban Population Study (CUPS)
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DOI：
10.1007/s001250051334
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发表时间：
2000-04-01
期刊：
影响因子：
8.2
通讯作者：
Deepa, R
中科院分区：
文献类型：
--
作者：
Mohan, V;Ravikumar, R;Deepa, R
目的/假设。颈动脉内膜中层厚度（IMT）增加被认为是动脉粥样硬化的一个有用的标志。本研究的目的是比较城市非糖尿病和糖尿病的南印度受试者谁有冠状动脉疾病的高风险的内膜中层厚度值。本研究的受试者为140名糖尿病患者和103名非糖尿病对照受试者，这些受试者的年龄和性别与选自Chennai城市人口研究的受试者相匹配，该研究是一项正在进行的流行病学研究。采用高分辨率B型超声测量右颈总动脉内膜中层厚度。糖尿病受试者的平均内膜中层厚度值（0.95 ± 0.31 mm）显著高于非糖尿病受试者（0.74 ± 0.14 mm）（p < 0.001）。在正常和糖尿病受试者中，这些值随着年龄的增长而增加。在任何给定的年龄，糖尿病受试者具有比非糖尿病受试者更高的值，但是在50岁之后差异达到统计学显著性（p <0.05）。内膜中膜厚度显示与非糖尿病受试者的年龄、总胆固醇、LDL胆固醇、腰臀比和收缩压相关，并且与糖尿病受试者的年龄和糖尿病持续时间相关。多元线性回归分析显示年龄和糖尿病是内膜中层厚度的主要危险因素。糖尿病受试者的内膜中层厚度值高于非糖尿病受试者。糖尿病和年龄是与南印度队列中内膜中层厚度增加相关的最重要的危险因素。
Aim/hypothesis. Increased intimal medial thickness (IMT) of the carotid arteries is considered a useful marker of atherosclerosis. The aim of this study was to compare the intimal medial thickness values in urban non-diabetic and diabetic South Indian subjects who have a high risk of coronary artery disease.Methods. The subjects for this study were 140 diabetic and 103 non-diabetic control subjects matched with them for age and sex selected from The Chennai Urban Population Study which is an ongoing epidemiological study. Intimal medial thickness of the right common carotid artery was determined using high resolution B mode ultrasonography,Results. The mean intimal medial thickness values of the diabetic subjects (0.95 +/- 0.31 mm) were significantly higher than those of the non-diabetic (0.74 +/- 0.14 mm) subjects (p < 0.001). Both in the normal and diabetic subjects, these values increased with age. At any given age, the diabetic subjects had higher values than the non-diabetic subjects but the difference reached statistical significance after age 50 years (p < 0,05),Intimal medial thickness showed a correlation with age, total cholesterol, LDL cholesterol, waist:hip ratio and systolic blood pressure in non-diabetic subjects and with age and duration or diabetes in the diabetic subjects. Multivariate linear regression analysis showed that age and diabetes were the major risk factors for intimal medial thickness.Conclusion/Interpretation. Diabetic subjects have higher intimal medial thickness values than non-diabetic subjects. Diabetes and age are the most important risk factors associated with increased intimal medial thickness in this South Indian cohort.