Alterations of Emotional and Cognitive Behaviors in Matrix Metalloproteinase-2 and -9-Deficient Mice
Alterations of Emotional and Cognitive Behaviors in Matrix Metalloproteinase-2 and -9-Deficient Mice
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DOI：
10.2174/1874230001004010019
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发表时间：
2010-09
期刊：
影响因子：
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通讯作者：
H. Mizoguchi;D. Ibi;K. Takuma;Yuko Kitahara;E. Tóth;J. Sato;S. Itohara;T. Nabeshima;Kiyofumi Yamada
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文献类型：
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作者：
H. Mizoguchi;D. Ibi;K. Takuma;Yuko Kitahara;E. Tóth;J. Sato;S. Itohara;T. Nabeshima;Kiyofumi Yamada
基质金属蛋白酶（MMPs）的功能是重塑细胞周围环境，从而在神经回路的重塑中发挥至关重要的作用。在本研究中，我们研究了MMP-2和MMP-9在情绪和认知功能中的作用，使用MMP-2和MMP-9基因靶向缺失的小鼠。MMP-9-（-/-）小鼠的情绪行为发生了改变，而MMP-2-（-/-）小鼠的情绪行为没有发生改变，这表现在旷场和高架十字臂迷宫测试中。MMP-9-（-/-）小鼠表现出长期物体识别记忆和条件性恐惧记忆的损伤。MMP-2-（-/-）小鼠在学习和记忆方面没有缺陷。提示内源性MMP-9在情绪和认知行为中发挥作用，可能与活动依赖性突触可塑性和脑发育有关。
Matrix metalloproteinases (MMPs) function to remodel the pericellular environment, and thereby play a crucial role in the remodeling of neural circuits. In the present study, we investigated the role of MMP-2 and MMP-9 in emotional and cognitive function using mice with targeted deletions of the MMP-2 and MMP-9 genes. Emotional behaviors of MMP-9-(-/-) mice but not MMP-2-(-/-) mice were altered, which was manifested in performances in the open-field and elevated plus-arm maze tests. MMP-9-(-/-) mice showed impairments in long-term object recognition memory and conditioned fear memory. MMP-2-(-/-) mice had no deficits in learning and memory. These findings suggest that endogenous MMP-9 play a role in emotional and cognitive behaviors, which may possibly be related to activity- dependent synaptic plasticity and brain development.