Application of Polyhydroxyalkanoates Nanoparticles as Intracellular Sustained Drug-Release Vectors
Application of Polyhydroxyalkanoates Nanoparticles as Intracellular Sustained Drug-Release Vectors
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DOI：
10.1163/156856209x410283
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发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Chen, Guo-Qiang
中科院分区：
文献类型：
--
作者：
Xiong, Yu-Cui;Yao, Yong-Chao;Chen, Guo-Qiang
Polyhydroxybutyrate (PHB), co-polyesters of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx), and polylactic acid (PLA) were used to prepare nanoparticles with average sizes of 160, 250 and 150 nm, respectively. A lipid-soluble colorant, rhodamine B isothiocyanate (RBITC), was employed to study drug-release behaviors from these nanoparticles. A high RBITC drug-loading efficiency of over 75% was achieved with all PHA nanoparticles prepared. Macrophage endocytosis led to an intracellular RBITC drug sustained release over a period of at least 20 days for PHB and PHBHHx nanoparticles, while PLA nanoparticles and free drug lasted only 15 days and a week, respectively. Polymer properties and particle sizes showed little effect on drug-release behavior. This study showed for the first time that PHB and PHBHHx can be used effectively to achieve intracellular controlled drug releases. (c) Koninklijke Brill NV, Leiden, 2010
