Modeling the Effect of Reactive Oxygen Species and CTL Immune Response on HIV Dynamics
Modeling the Effect of Reactive Oxygen Species and CTL Immune Response on HIV Dynamics
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DOI：
10.1142/s0218127421502035
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发表时间：
2021-10
期刊：
影响因子：
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通讯作者：
Q. Deng;Ting Guo;Zhipeng Qiu;L. Rong
中科院分区：
文献类型：
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作者：
Q. Deng;Ting Guo;Zhipeng Qiu;L. Rong
感染人类免疫缺陷病毒（HIV）的个体由于活性氧（ROS）的产生和消除之间的不平衡而处于氧化应激状态。本文提出了一个具有细胞毒性T淋巴细胞（CTL）免疫反应的数学模型，以研究活性氧在HIV感染动力学中的作用。我们对模型的平衡点进行了分类，并研究了这些平衡点的稳定性。数值模拟表明，将活性氧和CTL免疫反应纳入模型导致非常丰富的动力学，包括振荡现象和周期解。尽管目前的抗逆转录病毒疗法可以将病毒载量抑制到检测不到的水平，但它不能根除病毒。高水平的ROS可能是HIV持续存在的一个因素，尽管患者接受了抑制治疗。这些结果表明，在艾滋病毒感染和治疗的研究中应考虑氧化损伤和抗氧化治疗。
Individuals infected by human immunodeficiency virus (HIV) are under oxidative stress due to the imbalance between reactive oxygen species (ROS) production and elimination. This paper presents a mathematical model with the cytotoxic T lymphocytes (CTL) immune response to examine the role of ROS in the dynamics of HIV infection. We classify the equilibria of the model and study the stability of these equilibria. Numerical simulations show that incorporating ROS and CTL immune response into the model leads to very rich dynamics, including bistable phenomena and periodic solutions. Although the current antiretroviral therapy can suppress viral load to the undetectable level, it cannot eradicate the virus. A high level of ROS may be a factor for HIV persistence in patients despite suppressive therapy. These results suggest that oxidative damage and anti-oxidant therapy should be considered in the study of HIV infection and treatment.