Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits.
Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits.
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DOI：
10.2147/ndt.s265774
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发表时间：
2020
影响因子：
3.2
通讯作者：
Otani K
中科院分区：
文献类型：
--
作者：
Noto K;Suzuki A;Shirata T;Matsumoto Y;Takahashi N;Goto K;Otani K
依恋研究表明，童年时期与父母的依恋经历影响人格特质的表征。同时，已知μ-阿片受体功能涉及人类依恋。此外，一些研究表明，μ阿片受体基因（OPRM 1）的A118 G多态性与μ阿片受体功能的改变有关。因此，我们研究了OPRM 1多态性是否会调节对父母行为的敏感性，从而有助于人格特质的表征。研究对象为725名健康的日本人。父母教养方式采用父母教养方式量表（PBI），包括照顾和保护分量表。人格评估使用气质和性格量表（TCI）。采用PCR方法检测OPRM 1基因A118 G多态性。多元回归分析显示，OPRM 1基因型和母亲保护之间的交互作用对自我导向和合作维度的得分有显著影响，OPRM 1基因型对TCI总分的主效应不显著，进一步分析表明，母亲保护得分与A/A和A/B两个维度得分呈显著负相关。G基因型与前者相关系数较高，而与G/G基因型相关系数不高。本研究表明，OPRM 1基因多态性有助于人格特质的表征，通过调节对父母行为的敏感性，特别是母亲的保护。
Attachment research shows that attachment experiences with parents in childhood influence the characterization of personality traits. Meanwhile, it is known that mu-opioid receptor function is involved in human attachment. Furthermore, a few studies suggest that the A118G polymorphism of the mu-opioid receptor gene (OPRM1) is associated with altered mu-opioid receptor function. Thus, we examined if the OPRM1 polymorphism moderates the sensitivity to parental behaviors and thereby contributes to the characterization of personality traits. Participants were 725 healthy Japanese. Parenting practices of their parents were evaluated by the Parental Bonding Instrument (PBI) with the care and protection subscales. Personality was evaluated using the Temperament and Character Inventory (TCI). The OPRM1 A118G polymorphism was detected by a PCR method. Multiple regression analyses revealed significant effects of the interaction between the OPRM1 genotype and maternal protection on scores of the self-directedness and cooperativeness dimensions, while significant main effects of the OPRM1 genotype on scores of the TCI were not found. Further analyses showed that there were significant negative correlations between maternal protection scores and the two dimensional scores in the A/A and A/G genotypes with higher correlation coefficients in the former, but not in the G/G genotype. The present study suggests that the OPRM1 polymorphism contributes to the characterization of personality traits by moderating the sensitivity to parental behaviors, especially maternal protection.