Impact of dietary sodium intake on left ventricular diastolic filling in early essential hypertension
Impact of dietary sodium intake on left ventricular diastolic filling in early essential hypertension
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DOI：
10.1053/euhj.1997.0854
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发表时间：
1998-06-01
影响因子：
39.3
通讯作者：
Schmieder, RE
中科院分区：
文献类型：
--
作者：
Langenfeld, RW;Schobel, H;Schmieder, RE
目的研究饮食钠摄入量对高血压病左室肥厚的调节作用，不依赖于血压水平。本研究旨在阐明早期高血压患者钠摄入量与左心室结构或功能改变的关系。方法对44例年龄为25.9±-2.6岁的男性轻度高血压患者和45例血压正常的男性对照组进行研究。结果高血压病患者每日钠排泄量与最大血流速度(Vmax A/E；r=+0.2 7，P=0.0 7)、血流速度时间积分(A/E；r=+0.5 4，P
Aims Dietary sodium intake modulates left ventricular hypertrophy in established essential hypertension independent of blood pressure level. We conducted this study to elucidate the relationship between sodium intake and left ventricular structural or functional changes in early essential hypertension.Methods Forty-four young male patients (age 25.9 +/- 2.6 years) with mild essential hypertension that had never been treated and 45 normotensive male control subjects of similar age were examined. Dietary sodium intake was measured from 24 h urinary sodium excretion, blood pressure from 24 h ambulatory monitoring (SpaceLabs 90207), left ventricular structure from 2-D guided M-mode echocardiography, and diastolic filling of the left ventricle las the main compound of diastolic function in a young population) by pulse-wave Doppler sonography.Results In hypertensive patients, daily sodium excretion correlated with the ratio of late (A) to early (E) maximum velocity (Vmax A/E; r= +0.27, P=0.07), velocity time integrals (A/E; r=+054, P