Sparing of suppressor cells: a critical action of cyclosporine.
Sparing of suppressor cells: a critical action of cyclosporine.
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保护抑制细胞：环孢菌素的关键作用。
DOI：
10.1097/00007890-198408000-00001
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发表时间：
1984
期刊：
影响因子：
6.2
通讯作者：
Tilney,NL
中科院分区：
文献类型：
--
作者：
Kupiec-Weglinski,JW;Filho,MA;Strom,TB;Tilney,NL
1976年，Borel等人首次报道了环孢菌素（Cys）的显著免疫抑制特性（1）;随后，发表了大量关于其作用和影响的研究（2-5）。一段时间以来，我们和其他人已经积累了越来越多的证据表明，这种药物的关键作用机制之一，至少在实验动物中，涉及T抑制细胞（Ts）2的相对保留，这反过来又使宿主对同种异体移植组织耐受。在这篇综述中，我们提出了这个概念的证据。
The remarkable immunosuppressive properties of cyclosporine (Cys) were first reported by Borel et al. in 1976 (1); subsequently, a plethora of investigations on its actions and effects has been published (2–5). For some time, we and others have accrued increasing evidence that one of the critical mechanisms of action of this agent, at least in experimental animals, involves a relative sparing of T suppressor cells (Ts) 2 which in turn, renders the host tolerant toward allografted tissues. In this review, we present evidence for this concept.