Zebrafish genomics: from mutants to genes.

Zebrafish genomics: from mutants to genes.
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斑马鱼基因组学:从突变体到基因。

DOI:
10.1016/s0168-9525(97)01129-3
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发表时间:
1997
期刊:
Trends in genetics : TIG
影响因子:
--
通讯作者:
Talbot,WS
Talbot,WS
中科院分区:
--
文献类型:
--
作者:
Postlethwait,JH;Talbot,WS

文献摘要

被引文献

相似文献

在斑马鱼发育所必需的数百个基因中,已经分离出了精美的胚胎致死突变。对这一资源的分析有望增强我们对脊椎动物发育的分子遗传机制的理解。这篇综述讨论了斑马鱼基因组计划的状态和遗传诡计,可以加快这些突变破坏的基因的分子分离。
Exquisite embryonic lethal mutations have been isolated in hundreds of genes necessary for zebrafish development. Analysis of this resource promises to enhance our understanding of the molecular genetic mechanisms of vertebrate development. This review discusses the state of the zebrafish genome project and the genetic trickery that can expedite molecular isolation of genes disrupted by these mutations.