An Obesity-Associated FTO Gene Variant and Increased Energy Intake in Children
An Obesity-Associated FTO Gene Variant and Increased Energy Intake in Children
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DOI：
10.1056/nejmoa0803839
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发表时间：
2008-12-11
影响因子：
158.5
通讯作者：
Palmer, Colin N. A.
中科院分区：
文献类型：
--
作者：
Cecil, Joanne E.;Tavendale, Roger;Palmer, Colin N. A.
背景：脂肪量和肥胖相关（FTO）基因的变异是迄今为止与普通肥胖关联最为紧密的。然而，FTO变异在调节能量平衡的特定成分中所起的作用尚不明确。
方法：我们研究了2726名4至10岁的苏格兰儿童，对他们进行了FTO基因变异rs9939609的基因分型，并测量了身高和体重。对97名儿童的一个子样本进行了检查，以了解FTO变异与肥胖程度、能量消耗和食物摄入之间可能存在的关联。
结果：在整个研究组和子样本中，rs9939609的A等位基因与体重增加（分别为P = 0.003和P = 0.049）以及体重指数增加（分别为P = 0.003和P = 0.03）相关。在进行了详细表型分析的子样本中，A等位基因还与脂肪量增加（P = 0.01）相关，但与瘦体重无关。尽管携带A等位基因的儿童总能量消耗和静息能量消耗均增加（分别为P = 0.009和P = 0.03），但静息能量消耗与根据儿童年龄和体重预测的值相同，这表明携带风险相关等位基因的人在对肥胖的代谢适应方面没有缺陷。A等位基因与能量摄入增加（P = 0.006）相关，且与体重无关。相反，携带该等位基因的儿童摄入的食物重量与未携带该等位基因的儿童相似（P = 0.82）。
结论：赋予肥胖易感性的FTO变异似乎不参与能量消耗的调节，但可能在食物摄入和食物选择的控制中起作用，这表明与贪食表型或对高能量食物的偏好存在联系。
Background: Variation in the fat mass and obesity-associated (FTO) gene has provided the most robust associations with common obesity to date. However, the role of FTO variants in modulating specific components of energy balance is unknown.Methods: We studied 2726 Scottish children, 4 to 10 years of age, who underwent genotyping for FTO variant rs9939609 and were measured for height and weight. A subsample of 97 children was examined for possible association of the FTO variant with adiposity, energy expenditure, and food intake.Results: In the total study group and the subsample, the A allele of rs9939609 was associated with increased weight (P=0.003 and P=0.049, respectively) and body-mass index (P=0.003 and P=0.03, respectively). In the intensively phenotyped subsample, the A allele was also associated with increased fat mass (P=0.01) but not with lean mass. Although total and resting energy expenditures were increased in children with the A allele (P=0.009 and P=0.03, respectively), resting energy expenditure was identical to that predicted for the age and weight of the child, indicating that there is no defect in metabolic adaptation to obesity in persons bearing the risk-associated allele. The A allele was associated with increased energy intake (P=0.006) independently of body weight. In contrast, the weight of food ingested by children who had the allele was similar to that in children who did not have the allele (P=0.82).Conclusions: The FTO variant that confers a predisposition to obesity does not appear to be involved in the regulation of energy expenditure but may have a role in the control of food intake and food choice, suggesting a link to a hyperphagic phenotype or a preference for energy-dense foods.