Seasonal induction of GABAergic excitation in the central mammalian clock
Seasonal induction of GABAergic excitation in the central mammalian clock
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DOI：
10.1073/pnas.1319820111
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发表时间：
2014-07-01
影响因子：
11.1
通讯作者：
Michel, Stephan
中科院分区：
文献类型：
--
作者：
Farajnia, Sahar;van Westering, Tirsa L. E.;Michel, Stephan
兴奋和抑制之间的平衡对于大脑中神经元网络的正常功能是必不可少的。抑制性神经递质γ-氨基丁酸(GABA)参与视交叉上核(SCN)内的网络动力学，参与季节性编码。我们研究了暴露在短日照光周期中的小鼠SCN神经元的GABA能活性，并观察到主要的抑制作用。值得注意的是，在长日光周期中，GABA能活性从抑制转向兴奋。其机制基础似乎是改变了GABA诱发电流的平衡电位。这些结果强调，环境条件可能会对中枢神经系统中一种关键神经递质的功能产生实质性影响。
The balance between excitation and inhibition is essential for the proper function of neuronal networks in the brain. The inhibitory neurotransmitter gamma-aminobutyric acid (GABA) contributes to the network dynamics within the suprachiasmatic nucleus (SCN), which is involved in seasonal encoding. We investigated GABAergic activity and observed mainly inhibitory action in SCN neurons of mice exposed to a short-day photoperiod. Remarkably, the GABAergic activity in a long-day photoperiod shifts from inhibition toward excitation. The mechanistic basis for this appears to be a change in the equilibrium potential of GABA-evoked current. These results emphasize that environmental conditions can have substantial effects on the function of a key neurotransmitter in the central nervous system.