Should radiotherapy be avoided or delivered differently in elderly patients with rectal cancer?
Should radiotherapy be avoided or delivered differently in elderly patients with rectal cancer?
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DOI：
10.1016/j.ejca.2007.06.014
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发表时间：
2007-10-01
影响因子：
8.4
通讯作者：
Vulto, J. C. M.
中科院分区：
文献类型：
--
作者：
Martijn, H.;Vulto, J. C. M.
目的是概述直肠癌随时间推移的治疗可能性，以及直肠癌的实际治疗，特别是与年龄相关的治疗。从文献检索中对可切除直肠癌患者的代表性随机研究进行了回顾，仅比较了手术、术后和术前放疗加或不加化疗。我们还回顾了基于人群的研究中描述的有关直肠癌放疗的文献。试验概述表明，与无放疗或术后放疗相比，术前放疗可改善局部控制。添加化疗并没有显着提高生存率。年龄和并发症之间没有发现任何关系。所有基于人群的研究均表明，年龄的增加与（新）辅助治疗的减少相关。为了避免局部复发，应对所有可切除直肠癌患者（无论年龄）给予最佳可能的治疗，即术前放疗。 (C) 2007 Elsevier Ltd. 保留所有权利。
Purpose is to give an over-view of treatment possibilities of rectal cancer over time, but also of the real management of rectal cancer especially in relation to age. From literature search representative randomised studies on patients with resectable rectal cancer, comparing only surgery, post- and preoperative radiotherapy with or without chemotherapy, are reviewed. We also reviewed the literature regarding radiotherapy for rectal cancer described in population -based studies.The overview of the trials showed that preoperative radiotherapy improves local control in relation to no or postoperative radiotherapy. Adding chemotherapy did not significantly improve survival. No relations were seen between age and complications. All population-based studies showed that increasing age is associated with less (neo)adjuvant treatment.To avoid local recurrence, the best possible treatment, being preoperative RT, should be given to all patients with resectable rectal cancer, irrespective of age. (C) 2007 Elsevier Ltd. All rights reserved.