Macrocephaly in Children With Autism Spectrum Disorders
Macrocephaly in Children With Autism Spectrum Disorders
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DOI：
10.1016/j.pediatrneurol.2010.09.011
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发表时间：
2011-02-01
影响因子：
3.8
通讯作者：
Hatz, Julie K. Ivey
中科院分区：
文献类型：
--
作者：
Barnard-Brak, Lucy;Sulak, Tracey;Hatz, Julie K. Ivey
研究表明，与正常发育的同龄人相比，患有自闭症和谱系相关疾病的儿童存在巨头症或异常大的头围。然而，之前的研究主要集中在非全国代表性的、基于临床的自闭症谱系障碍儿童和成人样本上。此外，这些样本通常很小。本研究代表了来自早期儿童纵向研究出生队列的具有全国代表性、以社区为基础的患有和不患有自闭症谱系障碍儿童样本的结果。结果显示，与没有自闭症谱系障碍的儿童相比，在三个时间点上患有自闭症谱系障碍的儿童的头围在统计学上没有显着差异。这些结果可能被认为具有高度普遍性，因为它们是来自早期儿童纵向研究出生队列中具有或不具有自闭症谱系障碍的儿童的全国代表性、基于社区的样本。 (C) 2011 Elsevier Inc. 保留所有权利。
Research indicates the presence of macrocephaly or abnormally large head circumferences in children with autism and spectrum-related disorders, compared with their typically developing peers. Previous research, however, centered on non-nationally representative, clinic-based samples of children and adults with autism spectrum disorders. Moreover, these samples were typically small. The present study represents results of a nationally representative, community-based sample of children with and without autism spectrum disorders, derived from the Early Childhood Longitudinal Study Birth Cohort. Results reveal statistically nonsignificant differences in the head circumferences of children with autism spectrum disorders across three time points, compared with children without autism spectrum disorders. These results may be considered highly generalizable, because they are derived from a nationally representative, community-based sample of children with and without autism spectrum disorders from the Early Childhood Longitudinal Study Birth Cohort. (C) 2011 Elsevier Inc. All rights reserved.