Serum protein adsorption and excretion pathways of metal nanoparticles.
Serum protein adsorption and excretion pathways of metal nanoparticles.
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DOI：
10.2217/nnm.15.97
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Zheng J
中科院分区：
文献类型：
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作者：
Vinluan RD 3rd;Zheng J
虽然具有迷人的光学和电子特性的金属纳米颗粒（NPs）的合成在过去十年中取得了显着进展，并且其潜在的生物医学应用也得到了很好的证明，但由于其在体内的严重积累，将金属NPs转化为临床实践仍然是一个挑战。在此，我们简要回顾了金属纳米颗粒的尺寸依赖性材料特性及其潜在的生物医学应用，然后总结了尺寸，形状和电荷等结构参数如何影响它们与血清蛋白吸附，细胞摄取和排泄途径的相互作用。最后，我们还讨论了在最大限度地减少血清蛋白吸附和加快金属纳米颗粒的临床转化方面的未来挑战。
While the synthesis of metal nanoparticles (NPs) with fascinating optical and electronic properties have progressed dramatically and their potential biomedical applications were also well demonstrated in the past decade, translation of metal NPs into the clinical practice still remains a challenge due to their severe accumulation in the body. Herein, we give a brief review on size-dependent material properties of metal NPs and their potential biomedical applications, followed by a summary of how structural parameters such as size, shape and charge influence their interactions with serum protein adsorption, cellular uptake and excretion pathways. Finally, the future challenges in minimizing serum protein adsorption and expediting clinical translation of metal NPs were also discussed.