Diminished heart rate reactivity to acute psychological stress is associated with enhanced carotid intima-media thickness through adverse health behaviors
Diminished heart rate reactivity to acute psychological stress is associated with enhanced carotid intima-media thickness through adverse health behaviors
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DOI：
10.1111/psyp.12640
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发表时间：
2016-06-01
期刊：
影响因子：
3.7
通讯作者：
de Rooij, Susanne R.
中科院分区：
文献类型：
--
作者：
Ginty, Annie T.;Williams, Sarah E.;de Rooij, Susanne R.
最近的证据表明，对急性心理压力有低心率（HR）反应的人更有可能是肥胖或吸烟者。吸烟和肥胖是颈动脉内膜中层厚度（IMT）增加的既定危险因素。本研究的目的是检查连接内膜中层厚度、吸烟、体重指数（BMI）和HR应激反应性的潜在途径。共有552名参与者，47.6%的男性，M（SD）年龄=58.3（0.94）岁，暴露于三个心理应激任务（Stroop，镜子绘图，和语音）之前的休息基线期; HR记录整个。HR反应性计算为三项任务的平均反应减去平均基线HR。吸烟状况、BMI和IMT由受过培训的人员确定。控制重要的协变量（例如，社会经济地位），结构方程模型显示BMI和吸烟介导了HR反应性和IMT之间的负相关关系。假设模型显示出与数据的良好总体拟合，chi（2）（8）= 0.692，p= 0.403; CFI = 1.00; TLI = 1.00 SRMR = 0.01; RMSEA <0.001（90%CI < 0.01-0.11）。HR反应性与BMI（β =-0.16）和吸烟（β =-0.18）呈负相关，而这些又与IMT呈正相关（BMI：β = 0.10;吸烟：β = 0.17）。HR应激反应性降低似乎是IMT扩大的标志物，并且似乎通过已经确定的风险发挥其影响。未来的研究应该纵向研究这种关系，并旨在早期干预。
Recent evidence demonstrates that individuals with low heart rate (HR) reactions to acute psychological stress are more likely to be obese or smokers. Smoking and obesity are established risk factors for increased carotid intima-media thickness (IMT). The aim of this study was to examine the potential pathways linking intima-media thickness, smoking, body mass index (BMI), and HR stress reactivity. A total of 552 participants, 47.6% male, M (SD) age=58.3 (0.94) years, were exposed to three psychological stress tasks (Stroop, mirror drawing, and speech) preceded by a resting baseline period; HR was recorded throughout. HR reactivity was calculated as the average response across the three tasks minus average baseline HR. Smoking status, BMI, and IMT were determined by trained personnel. Controlling for important covariates (e.g., socioeconomic status), structural equation modeling revealed that BMI and smoking mediated the negative relationship between HR reactivity and IMT. The hypothesized model demonstrated a good overall fit to the data, chi(2) (8) = 0.692, p=.403; CFI = 1.00; TLI = 1.00 SRMR = .01; RMSEA < .001 (90% CI < 0.01-0.11). HR reactivity was negatively related to BMI (beta = -.16) and smoking (beta = -.18), and these in turn were positively associated with IMT (BMI: beta = .10; smoking: beta = .17). Diminished HR stress reactivity appears to be a marker for enlarged IMT and appears to be exerting its impact through already established risks. Future research should examine this relationship longitudinally and aim to intervene early.