Multi-layered functional membranes for periodontal regeneration: Preparation and characterization
Multi-layered functional membranes for periodontal regeneration: Preparation and characterization
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DOI：
10.1016/j.matlet.2016.05.054
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发表时间：
2016-09-01
影响因子：
3
通讯作者：
Gumusderelioglu, Menemse
中科院分区：
文献类型：
--
作者：
Gurbuz, Suhan;Demirtas, T. Tolga;Gumusderelioglu, Menemse
采用静电纺丝和溶剂浇注/颗粒浸出相结合的方法制备了多层生物可降解膜(MLM)。MLM具有三层不同的功能特性：聚己内酯(PCL)/纳米羟基磷灰石核心层和核心层两侧的PCL/胶原、PCL/胶原-骨形态发生蛋白7(BMP-7)外层。MC3T3-E1细胞培养实验表明，PCL/胶原BMP-7复合层可促进成骨细胞分化。这种简便的方法为制备用于牙周再生的多功能屏障膜以及具有不同性质的支架以模拟具有稳定完整性的复杂细胞外基质结构提供了巨大的潜力。(C)2016爱思唯尔B.V.保留所有权利。
Multi-layered biodegradable membranes (MLMs) were fabricated by combining electrospinning and solvent casting/particulate leaching methods. MLMs possess three layers of different functional properties; poly (caprolactone) (PCL)/nano-hydroxyapatite core layer and PCL/collagen, PCL/collagen-bone morphogenic protein 7 (BMP 7) outer layers on each side of the core layer. MC3T3-E1 cell culture tests showed that osteoblastic differentiation was enhanced on PCL/collagen BMP 7 layer. This facile method presents great potential for fabrication of multi-functional barrier membranes for periodontal regeneration as well as scaffolds possessing different properties to mimic complex extra cellular matrix structures with stable integrity. (C) 2016 Elsevier B.V. All rights reserved.