The effect of varying frequency and intensity of transcutaneous electrical nerve stimulation on secondary mechanical hyperalgesia in an animal model of inflammation
The effect of varying frequency and intensity of transcutaneous electrical nerve stimulation on secondary mechanical hyperalgesia in an animal model of inflammation
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DOI：
10.1054/jpai.2001.19963
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发表时间：
2001-04-01
期刊：
影响因子：
4
通讯作者：
Sluka, KA
中科院分区：
文献类型：
--
作者：
King, EW;Sluka, KA
多年来，经皮电神经刺激（TENS）已被临床用于治疗多种类型的疼痛。虽然已经有许多关于TENS在临床环境中的疗效的研究，但结果是相互矛盾的。本研究的目的是确定不同频率和强度的TENS对急性关节炎引起的继发性机械性痛觉过敏的影响。将3%角叉菜胶和3%高岭土的混合物（100穆尔在0.9%无菌盐水中）注射到雄性Sprague-Dawley大鼠的一个膝关节腔中。在膝关节炎症之前确定对机械刺激的反应阈值;炎症后4小时; TENS给药后立即（炎症后约5小时）;以及炎症后8、12和24小时。TENS被应用于发炎的膝关节在高（100赫兹）或低（4赫兹）的频率和在任何一个感官或运动强度。感觉强度刚好低于运动收缩的阈值，运动强度是运动收缩阈值的2倍。低频或高频TENS在减少继发性机械性痛觉过敏方面同样成功。同样，感觉或运动强度TENS同样减少继发性机械痛觉过敏。因此，TENS的选择应基于患者的舒适度和缓解继发性机械性痛觉过敏的症状。
For years, transcutaneous electrical nerve stimulation (TENS) has been used clinically for the treatment of many types of pain. Although there have been many studies conducted on the efficacy of TENS in the clinical setting, the results are conflicting. The purpose of our investigation was to determine the effect of varying frequency and intensity of TENS on secondary mechanical hyperalgesia induced by acute joint inflammation. Male Sprague-Dawley rats were injected with a mixture of 3% carrageenan and 3% kaolin (100 muL in 0.9% sterile saline) into the joint cavity of one knee. The response threshold to mechanical stimuli was determined before inflammation of the knee joint; 4 hours after inflammation; immediately after the administration of TENS (approximately 5 hours after inflammation); and at 8, 12, and 24 hours after inflammation. TENS was applied to the inflamed knee joint at either high (100 Hz) or low (4 Hz) frequency and at either sensory or motor intensity. Sensory intensity was just below the threshold for motor contraction, and motor intensity was 2 x threshold for motor contraction. Either low- or high-frequency TENS is equally successful in reducing secondary mechanical hyperalgesia. Similarly, either sensory- or motor-intensity TENS equally reduces secondary mechanical hyperalgesia. Thus, selection of TENS should be based on patient comfort and symptoms for relief of secondary mechanical hyperalgesia.