Copper-Catalyzed Simultaneous Installation of Boryl and Carbonyl Functionalities to Unsaturated Hydrocarbons
Copper-Catalyzed Simultaneous Installation of Boryl and Carbonyl Functionalities to Unsaturated Hydrocarbons
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铜催化硼基和羰基官能团同时安装到不饱和烃上
DOI：
10.1002/ajoc.202200535
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
T. Fujihara
中科院分区：
文献类型：
--
作者：
小野 まりえ，浅井 駿輝，大木 靖弘，竹本 佳司，中 寛史;T. Fujihara
铜催化不饱和烃的硼基化官能化是在温和反应条件下合成各种有机硼化合物的有效方法。特别是，安装羰基官能团（例如酰基、甲酰基和羧基）很有趣，因为这些官能团在有机合成中起着重要作用。本综述重点关注使用铜催化剂在不饱和烃中安装硼基和羰基官能团。首先，讨论使用甲酸酯、酰基卤或酸酐的甲酰化和酰化反应。其次，总结了使用二氧化碳作为亲电子试剂同时引入硼基和羧基。第三，描述了使用亲电氰化试剂的不饱和烃的硼氰化。
Cu‐catalyzed borylative functionalization of unsaturated hydrocarbons is an effective method for synthesizing various organoboron compounds under mild reaction conditions. In particular, installing carbonyl functionalities such as acyl, formyl, and carboxy groups is interesting because of the essential role of these functionalities in organic synthesis. This review focuses on the installation of boryl and carbonyl functionalities in unsaturated hydrocarbons using Cu catalysts. First, formylation and acylation reactions using formate esters, acyl halides, or acid anhydrides are addressed. Second, the simultaneous incorporation of a boryl group and a carboxy group using carbon dioxide as the electrophile is summarized. Third, the borocyanation of unsaturated hydrocarbons using electrophilic cyanation reagents is described.