Antibodies to Streptococci pneumoniae in sera and secretions of mothers and their infants.
Antibodies to Streptococci pneumoniae in sera and secretions of mothers and their infants.
复制标题
母亲及其婴儿的血清和分泌物中的肺炎链球菌抗体。
DOI：
10.1007/978-1-4615-3838-7_43
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发表时间：
1991
影响因子：
--
通讯作者：
Reynolds,DW
中科院分区：
文献类型：
--
作者：
Gray,BM;PolhillJr,RB;Reynolds,DW
母乳通常含有针对各种常见病原体的抗体，流行病学证据表明，母乳喂养的婴儿较不容易受到某些胃肠道感染。1母乳喂养在预防呼吸道细菌方面的作用不太清楚，而且由于实际和社会因素决定了婴儿暴露在肺炎球菌等生物体中，这无疑是复杂的。2免疫保护机制被假定为存在特定类型的抗体；然而，没有关于母乳中肺炎球菌抗体的定量数据。在这篇文章中，我们描述了一项前瞻性的研究，对四种常见肺炎球菌血清型在母乳及其婴儿出生一年的血清和唾液中的抗体水平进行了研究。选择的肺炎球菌类型为6型、14型、19型和23型，这是与儿童早期携带和感染有关的最常见的类型。3由于这些被膜抗原中的一些在结构上与正常人分泌物中发现的寡糖相似，我们还研究了牛奶和唾液对类型特异性抗体与肺炎球菌多糖结合的抑制作用。
Human milk normally contains antibodies against a variety of common pathogens, and there is epidemiologic evidence that breast-fed infants are less susceptible to certain gastrointestinal infections.1The role of breastfeeding in protection against respiratory bacteria is less clear and is undoubtedly complicated by the practical and social factors that determine the exposure of infants to organisms such as the pneumococcus.2The immunological mechanism of protection is assumed to be the presence of type-specific antibodies; however, there are no quantitative data on antibodies to pneumococci in human milk. In this paper we describe a prospective study of antibody levels to four common pneumococcal serotypes in mothers’ milk and in the sera and saliva of their infants during the first year of life. The pneumococcal types selected were types 6, 14, 19, and 23, which are the most common types associated with carriage and infection in early childhood.3Because some of these capsular antigens bear structural similarities to oligosaccharides found in normal human secretions, we also studied the inhibitory effect of milk and saliva on the binding of type-specific antibodies to the pneumococcal polysaccharides.