Characterization of an influenza A virus in Mexican swine that is related to the A/H1N1/2009 pandemic clade
Characterization of an influenza A virus in Mexican swine that is related to the A/H1N1/2009 pandemic clade
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DOI：
10.1016/j.virol.2012.08.003
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发表时间：
2012-11-10
期刊：
影响因子：
3.7
通讯作者：
Arias, Carlos F.
中科院分区：
文献类型：
--
作者：
Escalera-Zamudio, Marina;Cobian-Gueemes, Georgina;Arias, Carlos F.
2009年春天，猪源性H1N1pdm09流感病毒引发了本世纪第一次流感大流行。我们对墨西哥疫情爆发初期传播的流感病毒进行了特征分析，包括一种新测序的猪 H1N1pdm09 病毒和三种新测序的人 H1N1pdm09 病毒，这些病毒在韦拉克鲁斯州 La Gloria 呼吸道疾病疫情中传播。系统发育分析显示，2009 年 4 月收集的猪分离株 (A/swine/Mexico/4/2009) 位于八个单基因树中的两个（NP 和 PA）中 H1N1pdm09 进化枝其余部分的基础分支中。此外，串联的HA-NA和完整的全基因组树也显示了A/swine/Mexico/4/2009的基础位置。此外，这种猪病毒被发现与非 HIN1pdm09 H1N1 病毒谱系具有相同的分子特征。这些结果表明，该分离株可能是从与 H1N1pdm09 病毒密切相关的姐妹谱系中检测到的第一个分离株。 (C) 2012 Elsevier Inc. 保留所有权利。
In the spring of 2009, swine-origin influenza H1N1pdm09 viruses caused the first influenza pandemic of this century. We characterized the influenza viruses that circulated early during the outbreak in Mexico, including one newly sequenced swine H1N1pdm09 virus and three newly sequenced human H1N1pdm09 viruses that circulated in the outbreak of respiratory disease in La Gloria, Veracruz. Phylogenetic analysis revealed that the swine isolate (A/swine/Mexico/4/2009) collected in April 2009 is positioned in a branch that is basal to the rest of the H1N1pdm09 clade in two (NP and PA) of the eight single-gene trees. In addition, the concatenated HA-NA and the complete whole-genome trees also showed a basal position for A/swine/Mexico/4/2009. Furthermore, this swine virus was found to share molecular traits with non-HIN1pdm09 H1N1 viral lineages. These results suggest that this isolate could potentially be the first one detected from a sister lineage closely related to the H1N1pdm09 viruses. (C) 2012 Elsevier Inc. All rights reserved.