Contrasting functions of IgG and IgE antimalarial antibodies in uncomplicated and severe Plasmodium falciparum malaria.
Contrasting functions of IgG and IgE antimalarial antibodies in uncomplicated and severe Plasmodium falciparum malaria.
复制标题
IgG 和 IgE 抗疟抗体在简单和严重恶性疟原虫疟疾中的功能对比。
DOI：
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发表时间：
2000
影响因子：
3.3
通讯作者：
Masamichi Aikawa
中科院分区：
文献类型：
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作者：
P. Perlmann;H. Perlmann;S. Looareesuwan;S. Krudsood;Shigeyuki Kano;Yoshitsugu Matsumoto;G. Brittenham;M. Troye;Masamichi Aikawa
疟原虫感染导致包括IgE在内的免疫球蛋白的血液浓度显著升高。两组特征良好的成年泰国患者无论是简单的或严重的恶性疟原虫疟疾进行了研究，为期四周。严重疟疾患者的平均寄生虫血症大约是无并发症疟疾患者的3倍。总IgG和IgG抗疟原虫抗体的平均浓度往往是最高的组与简单的疾病，而总IgE和IgE抗体较高的组与严重的疾病。在大约65%的患者中检测到的IgE抗体与寄生虫血症呈正相关。这些结果表明，抗疟原虫IgG抗体参与降低恶性疟原虫疟疾的严重程度，而IgE抗体可能有助于这种感染的发病机制。
Plasmodial infection results in a significant elevation of the blood concentrations of immunoglobulins including IgE. Two well-characterized groups of adult Thai patients with either uncomplicated or severe Plasmodium falciparum malaria were studied over a period of four weeks. The mean parasitemias were approximately three-fold higher in patients with severe malaria than in those with uncomplicated disease. The mean concentrations of both total IgG and IgG antiplasmodial antibodies tended to be highest in the group with uncomplicated disease while total IgE and IgE antibodies were higher in the group with severe disease. The IgE antibodies detected in approximately 65% of the patients were positively correlated to parasitemia. These results suggest that antiplasmodial IgG antibodies are involved in reducing the severity of P. falciparum malaria, while IgE antibodies may contribute to the pathogenesis of this infection.