Longitudinal Associations of Midlife Accelerometer Determined Sedentary Behavior and Physical Activity With Cognitive Function: The CARDIA Study.
Longitudinal Associations of Midlife Accelerometer Determined Sedentary Behavior and Physical Activity With Cognitive Function: The CARDIA Study.
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DOI：
10.1161/jaha.120.018350
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发表时间：
2021-02-02
影响因子：
5.4
通讯作者：
Yaffe K
中科院分区：
文献类型：
--
作者：
Whitaker KM;Zhang D;Pettee Gabriel K;Ahrens M;Sternfeld B;Sidney S;Jacobs DR Jr;Palta P;Yaffe K
确定加速度计测量的中年久坐行为（SED）、轻强度体力活动（LPA）和中等至高强度体力活动（MVPA）是否与认知功能前瞻性相关。参与者是参加CARDIA（年轻人冠状动脉风险发展）研究的1970名成年人，他们在2005年至2006年（年龄38-50岁）佩戴加速度计，并在5年和/或10年后完成认知功能评估。通过ActiGraph 7164加速度计测量SED、LPA和MVPA。认知功能测试包括数字符号替代测试、Rey听觉言语学习测试和Stroop测试。成分等时替代分析研究了SED、LPA和MVPA与认知功能标准化评分重复测量的相关性。在男性中，30分钟LPA与30分钟MVPA的统计学重新分配导致SD 0.07的估计差异（95% CI，0.01-0.14），SD 0.09（95% CI，0.02-0.17）和SD −0.11（95%CI，-0.19至-0.04）在数字符号替代测试，雷伊听觉语言学习测试和Stroop评分分别，表明更好的性能。当重新分配SED与MVPA的时间时，相关性相似，但结果不太稳健。SED与LPA的时间重新分配导致SD-0.05的估计差异（95% CI，−0.06至−0.03），SD −0.03（95% CI，−0.05至−0.01），SD 0.05（95% CI，0.03- 0.07）在数字符号替代测试，雷伊听觉语言学习测试，和Stroop评分，分别表示较差的性能。在妇女中，这种关联基本上不重要。我们的研究结果支持了这样一种观点，即对于男性来说，在中年时期可能需要更高强度的活动（MVPA）来观察与认知的有益联系。
To determine if accelerometer measured sedentary behavior (SED), light‐intensity physical activity (LPA), and moderate‐to‐vigorous–intensity physical activity (MVPA) in midlife is prospectively associated with cognitive function. Participants were 1970 adults enrolled in the CARDIA (Coronary Artery Risk Development in Young Adults) study who wore an accelerometer in 2005 to 2006 (ages 38–50 years) and had cognitive function assessments completed 5 and/or 10 years later. SED, LPA, and MVPA were measured by an ActiGraph 7164 accelerometer. Cognitive function tests included the Digit Symbol Substitution Test, Rey Auditory Verbal Learning Test, and Stroop Test. Compositional isotemporal substitution analysis examined associations of SED, LPA, and MVPA with repeated measures of the cognitive function standardized scores. In men, statistical reallocation of 30 minutes of LPA with 30 minutes of MVPA resulted in an estimated difference of SD 0.07 (95% CI, 0.01–0.14), SD 0.09 (95% CI, 0.02–0.17), and SD −0.11 (95% CI, −0.19 to −0.04) in the Digit Symbol Substitution Test, Rey Auditory Verbal Learning Test, and Stroop scores, respectively, indicating better performance. Associations were similar when reallocating time in SED with MVPA, but results were less robust. Reallocation of time in SED with LPA resulted in an estimated difference of SD −0.05 (95% CI, −0.06 to −0.03), SD −0.03 (95% CI, −0.05 to −0.01), and SD 0.05 (95% CI, 0.03– 0.07) in the Digit Symbol Substitution Test, Rey Auditory Verbal Learning Test, and Stroop scores, respectively, indicating worse performance. Associations were largely nonsignificant among women. Our findings support the idea that for men, higher‐intensity activities (MVPA) may be necessary in midlife to observe beneficial associations with cognition.