The Generation and Recognition of Positional Information in the Preimplantation Mouse Embryo
The Generation and Recognition of Positional Information in the Preimplantation Mouse Embryo
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植入前小鼠胚胎位置信息的生成和识别
DOI：
10.1007/978-1-4613-3180-3_5
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
A. Handyside
中科院分区：
文献类型：
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作者：
Martin H. Johnson;H. Pratt;A. Handyside
植入前小鼠胚胎内的细胞分化和定型取决于细胞位置（Mintz，1965; Tarkowski和Wroblewska，1967）。在形成桑椹胚的细胞聚集体中，位于中心的细胞群开始分化为内细胞团（ICM），而位于外周的细胞层分化为滋养外胚层。在这些第一个明显的分化迹象之后，这两类分化的细胞就固定在它们的发育过程中，因此被认为是定型的。如果在定型前，细胞位置因卵裂球重排而改变，那么细胞分化和命运都将改变（见Rossant，1977;约翰逊，1979; Rossant和Frels，本卷）。胚胎可以自我调节。
Cell differentiation and commitment within the preimplantation mouse embryo depend on cell position (Mintz, 1965; Tarkowski and Wroblewska, 1967). Within the aggregate of cells that form the morula, the more centrally placed cluster of cells starts to differentiate as an inner cell mass (ICM), while the more peripherally placed layer of cells differentiates as trophectoderm. After these first overt signs of differentiation, the two diverging classes of cells become fixed on their courses of development and are therefore said to be committed. If cell position is changed before commitment by rearrangement of blastomeres, then both cell differentiation and fate are changed (see Rossant, 1977; Johnson, 1979; Rossant and Frels, this volume). The embryo can regulate itself.