Placental structure and inflammation in pregnancies associated with obesity
Placental structure and inflammation in pregnancies associated with obesity
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DOI：
10.1016/j.placenta.2010.12.023
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发表时间：
2011-03-01
期刊：
影响因子：
3.8
通讯作者：
Denison, F. C.
中科院分区：
文献类型：
--
作者：
Roberts, K. A.;Riley, S. C.;Denison, F. C.
背景：妊娠前肥胖与母亲和后代的发病率和死亡率增加有关。最近的研究表明，妊娠前肥胖妇女全身和局部脂肪和胎盘组织内的炎症反应升高，这可能在介导不良妊娠结局中起作用。本研究的目的是描述肥胖妇女母体和胎盘的炎症状态，并调查胎盘结构的相关变化。方法：通过测量母体循环水平和胎盘促炎细胞因子基因表达，量化胎盘内的免疫细胞群，对47名非肥胖（BMI 20-25 kg/m(2)）和33名肥胖（>= 30 kg/m(2)）女性的促炎状态进行了表征。通过检查胎盘成熟度、血管密度、合胞结和芽的形成、纤维蛋白沉积程度、脉络膜增生和血管壁肌肉化来研究妊娠前肥胖对胎盘结构的影响。结果：产妇肥胖与IL-1 β (p < 0.05)、IL-8 （p < 0.05）、MCP-1 （p < 0.05）显著升高相关
Background: Pre-gravid obesity is associated with increased morbidity and mortality for both mother and offspring. Recent studies have demonstrated a heightened inflammatory response both systemically and locally within the adipose and placental tissue in women with pre-gravid obesity, which may play a role in mediating the adverse pregnancy outcomes. The aim of this study was to characterise the maternal and placental inflammatory status and investigate associated changes in placental structure in obese women.Methods: The pro-inflammatory status of a cohort of 47 non-obese (BMI 20-25 kg/m(2)) and 33 obese (>= 30 kg/m(2)) women was characterised by measuring maternal circulating levels and placental gene expression of pro-inflammatory cytokines, and quantifying immune cell populations within the placenta. The effect of pre-gravid obesity on placental structure was investigated by examining placental maturity, vessel density, the formation of syncytial knots and sprouts, and the degree of fibrin deposition, chorangiosis and muscularisation of vessel walls.Results: Maternal obesity was associated with significantly greater IL-1 beta (p < 0.05), IL-8 (p < 0.05), MCP-1 (p