Hormonal profile of diabetic men and the potential link to prostate cancer
Hormonal profile of diabetic men and the potential link to prostate cancer
复制标题
DOI：
10.1007/s10552-008-9133-x
复制
发表时间：
2008-09-01
影响因子：
2.3
通讯作者：
Giovannucci, Edward
中科院分区：
文献类型：
--
作者：
Kasper, Jocelyn S.;Liu, Yan;Giovannucci, Edward
目的 先前的研究表明，与没有糖尿病的男性相比，患有糖尿病的男性患前列腺癌的风险可能较低。为了研究潜在的生物学机制，比较了男性糖尿病患者和非糖尿病对照者的激素特征。方法在健康专业人员随访研究中，测定了 171 名糖尿病男性和 3,001 名非糖尿病对照者的 C 肽、睾酮、性激素结合球蛋白、胰岛素样生长因子 1 和胰岛素样生长因子结合蛋白 3 的血浆水平。进行多元线性回归分析，并计算感兴趣激素的最小二乘均值。 结果 检查糖尿病诊断后 15 年的几种激素的血浆水平。随着糖尿病诊断时间的增加，C 肽和 IGFBP-3 的血浆水平显着下降（趋势 p：C 肽 =.05，IGFBP-3 =.03）。虽然睾酮和性激素结合球蛋白水平随着糖尿病诊断后时间的增加而显着增加（趋势p：睾酮=.02，性激素结合球蛋白=.002），但睾酮与性激素结合球蛋白的比率下降，表明生物可利用的睾酮减少。糖尿病患者的血浆 IGF-1 水平低于非糖尿病患者，但没有观察到显着的时间趋势。结论 这项针对糖尿病男性与非糖尿病男性激素分布的研究发现，糖尿病男性的变化可能与前列腺癌风险降低一致。
Objective Previous studies suggest men with diabetes may be at reduced risk for prostate cancer as compared to men without diabetes. To investigate potential biological mechanisms, hormonal profiles of diabetic men and non-diabetic controls were compared.Methods In the Health Professionals Follow-Up Study, plasma levels of C-peptide, testosterone, sex-hormone binding globulin, insulin-like growth factor-1, and insulin-like growth factor binding protein-3 were determined in 171 diabetic men and 3,001 non-diabetic controls. Multiple linear regression analysis was conducted and least square means were calculated for hormones of interest.Results Plasma levels of several hormones either = 15 years after diagnosis with diabetes were examined. As time since diabetes diagnosis increased, plasma levels of C-peptide and IGFBP-3 significantly decreased (p for trend: C-peptide =.05, IGFBP-3 =.03). While testosterone and SHBG levels both significantly increased with increasing time since diabetes diagnosis (p for trend: testosterone =.02, SHBG =.002), the ratio of testosterone to SHBG decreased, suggesting a reduction in bioavailable testosterone. Plasma IGF-1 levels were lower in diabetics than non-diabetics, but no significant time trend was noted.Conclusion This study of hormonal profiles of diabetic versus non-diabetic men identified changes in diabetic men that may be consistent with reduced prostate cancer risk.