The Onset of Nonmotor Symptoms in Parkinson's Disease (The ONSET PD Study)
The Onset of Nonmotor Symptoms in Parkinson's Disease (The ONSET PD Study)
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DOI：
10.1002/mds.26077
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发表时间：
2015-02-01
影响因子：
8.6
通讯作者：
Tolosa, Eduardo
中科院分区：
文献类型：
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作者：
Pont-Sunyer, Claustre;Hotter, Anna;Tolosa, Eduardo
帕金森病（PD）的非运动症状（NMS）可先于运动症状发作。运动前症状发作和运动功能之间的关系是有限的。我们的目的是描述帕金森病中NMS的存在和感知发作，以及它们与运动表型的可能关联。在109例新诊断的未经治疗的PD患者和107例来自11个西班牙和奥地利中心的对照者中，通过定制的问卷评估了NMS的存在和发作。31例NMS患者中有17例较对照组多见（P
Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor symptoms. Relationship between premotor symptoms onset and motor features is limited. Our aim is to describe the presence and perceived onset of NMS in PD as well as their possible association with motor phenotype. Presence and onset of NMS were assessed by a custom-made questionnaire in 109 newly diagnosed untreated PD patients and 107 controls from 11 Spanish and Austrian centers. Seventeen of thirty-one NMS were more common in patients than controls (P