Alopecia areata as another immune-mediated disease developed in patients treated with tumour necrosis factor-α blocker agents
Alopecia areata as another immune-mediated disease developed in patients treated with tumour necrosis factor-α blocker agents
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DOI：
10.1111/j.1468-3083.2010.03770.x
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发表时间：
2011-04-01
影响因子：
9.2
通讯作者：
Maymo, J.
中科院分区：
文献类型：
--
作者：
Ferran, M.;Calvet, J.;Maymo, J.
背景肿瘤坏死因子拮抗剂（anti-TNF-α）已被证实对不同的慢性免疫炎症性疾病有效。在频谱的不良事件，自身免疫性疾病已被观察到，包括斑秃（AA）的情况下，ObjectivesThe目的的研究是AA开发抗TNF-α therapeutic.MethodsWe提出了五个新的情况下，并回顾了所有的情况下，在文献中报道（11）。大多数患者表现为迅速广泛的AA，通常累及蛇病区。预后通常较差，对治疗反应轻微。在保持抗TNF-α治疗的情况下，过程似乎并没有改变。ConclusionsAlthough罕见，AA开发抗TNF-α治疗过程中可能会更频繁比孤立病例的报告。自身免疫性疾病的个人和家族史可能会提醒临床医生，一旦开始抗TNF-α治疗，他们可能会发展或复发。
BackgroundTumour necrosis factor antagonists (anti-TNF-alpha) have demonstrated the efficacy in different chronic immune inflammatory disorders. Within the spectrum of adverse events, autoimmune diseases have been observed, including cases of alopecia areata (AA).ObjectivesThe objective of the study is to characterize AA developed during anti-TNF-alpha therapy.MethodsWe present five new cases and review all the cases reported in the literature (eleven).ResultsOne third of the cases had a positive (personal or family) history of AA. Most of them presented with rapid extensive AA, usually involving the ophiasis area. Prognosis was usually poor, with slight response to treatments. In the cases where anti-TNF-alpha therapy was maintained, the course did not seem to change.ConclusionsAlthough rare, AA developed during anti-TNF-alpha therapy might be more frequent than suggested by reports of isolated cases. Personal and family history of autoimmune disease might alert clinicians to their possible development or relapse once the anti-TNF-alpha therapy is started.