β-リン酸三カルシウム-ポリ乳酸共重合体複合体の生理食塩水中における機械的強度変化
β-リン酸三カルシウム-ポリ乳酸共重合体複合体の生理食塩水中における機械的強度変化
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β-磷酸三钙-聚乳酸共聚物复合物在生理盐水中机械强度的变化
DOI：
10.11451/mukimate1994.5.493
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发表时间：
1998
影响因子：
0.8
通讯作者：
田代 豊
中科院分区：
文献类型：
--
作者：
菊池 正紀;田中 順三;有賀 利郎;田代 豊
采用热捏合法制备了生物活性β-磷酸三钙（TCP）与可生物降解共聚聚丙交酯（CPLA）的新型复合材料。通过三点弯曲试验评价机械强度作为在生理盐水中浸泡时间的函数。复合材料的机械强度从 60 MPa 迅速下降至 30 MPa，并在浸泡后 4 周达到稳定水平，而纯 CPLA 的机械强度在最初 4 周内几乎恒定，并且由于 CPLA 的水解，从浸泡后 4 周开始迅速下降。 Ca浓度测量和SEM观察表明，复合材料机械强度的最初下降是由于TCP从表面溶解引起的，并且复合材料中的TCP抑制了CPLA的水解。这些结果表明TCP/CPLA复合材料在足够长的时间内保持强度，可以用作可生物降解的骨再生材料。
New composites of bioactive β-tricalcium phosphate (TCP) and biodegradable copolymerized poly-L-lactide (CPLA) were prepared by a heat-kneading method. Mechanical strength was evaluated by a three-point bending test as a function of soaking time in physiological saline. The mechanical strength of the composites rapidly decreased from 60 to 30 MPa and reached plateau 4 weeks after soaking, while that of pure CPLA was almost constant for the initial 4 weeks and rapidly decreased from 4 weeks after soaking due to the hydrolysis of CPLA. It was indicated from Ca concentration measurements and SEM observations that the initial decreasing in the mechanical strength of the composite was caused by the dissolution of TCP from the surface, and that TCP in the composite inhibited the hydrolysis of CPLA. These results showed that the TCP/CPLA composites kept the strength for sufficient period to use as biodegradable bone regeneration materials.