Finding a Niche: Tissue Immunity and Innate Lymphoid Cells.
Finding a Niche: Tissue Immunity and Innate Lymphoid Cells.
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寻找利基市场：组织免疫和先天淋巴细胞。
DOI：
10.1007/978-981-16-8387-9_5
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发表时间：
2022
影响因子：
--
通讯作者：
VanDyken,StevenJ
中科院分区：
文献类型：
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作者：
Jung,Haerin;Kim,Do-Hyun;Wang,Yilin;VanDyken,StevenJ
免疫系统在维持哺乳动物组织的稳态中起着重要作用，其范围超出病原体清除和宿主防御。最近，已经描述了由成对的造血细胞和非造血细胞组成的几种稳态回路在发育和扰动后影响组织组成和周转。关键回路组件包括先天性淋巴样细胞（ILC），其通过影响祖细胞命运决定、微生物相互作用和神经元活动来播种发育器官并塑造其驻留组织。当它们在组织中发育时，ILC经历转录印记，其编码对来自其驻留组织的相应信号的接受性，但ILC也可以改变其转录谱以适应特定类型的组织扰动。因此，ILC功能嵌入其驻留组织中，在那里它们构成可导致有益和致病结果的稳态应答的关键调节剂。在这里，我们研究了ILC和各种非造血组织细胞之间的相互作用，并讨论了特定的ILC组织细胞回路如何形成组织免疫的基本要素。
The immune system plays essential roles in maintaining homeostasis in mammalian tissues that extend beyond pathogen clearance and host defense. Recently, several homeostatic circuits comprised of paired hematopoietic and non-hematopoietic cells have been described to influence tissue composition and turnover in development and after perturbation. Crucial circuit components include innate lymphoid cells (ILCs), which seed developing organs and shape their resident tissues by influencing progenitor fate decisions, microbial interactions, and neuronal activity. As they develop in tissues, ILCs undergo transcriptional imprinting that encodes receptivity to corresponding signals derived from their resident tissues but ILCs can also shift their transcriptional profiles to adapt to specific types of tissue perturbation. Thus, ILC functions are embedded within their resident tissues, where they constitute key regulators of homeostatic responses that can lead to both beneficial and pathogenic outcomes. Here, we examine the interactions between ILCs and various non-hematopoietic tissue cells, and discuss how specific ILC-tissue cell circuits form essential elements of tissue immunity.