Sebaceous hyperplasia in organ transplant recipients: Shared aspects of hyperplastic and dysplastic processes?
Sebaceous hyperplasia in organ transplant recipients: Shared aspects of hyperplastic and dysplastic processes?
复制标题
DOI：
10.1016/s0190-9622(96)90723-9
复制
发表时间：
1996-11-01
影响因子：
13.8
通讯作者：
Simpson, NB
中科院分区：
文献类型：
--
作者：
deBerker, DAR;Taylor, AE;Simpson, NB
背景资料：接受肾脏或心脏移植的患者会出现广泛的皮肤变化，这主要归因于防止移植排斥所需的免疫抑制。除了感染，他们有一个不典型增生病变的发病率增加，其中一些是恶性的。目的：我们的目的是确定心脏和肾脏移植受体的皮脂腺增生的发病率及其与neoplasia.Methods：患者接受心脏移植从一个单一的移植中心进行了检查，在30个月的筛选期，以建立皮肤异常的患病率。结果：104例心脏移植受者中有16例（16%）有皮脂腺增生，而年龄和性别匹配的对照组中只有1%。结论：心脏移植受者存在皮脂腺增生。它似乎与骨质增生无关，据信毛囊皮脂腺单位是环孢素直接作用的靶点。我们认为，皮脂腺增生的发生与移植受者上皮增生异常的过程有关。
Background: Patients receiving kidney or heart transplants are subject to a wide range of cutaneous changes attributed largely to the immunosuppression required to prevent rejection of their transplant. In addition to infection, they have an increased incidence of dysplastic lesions, some of which are malignant.Objective: Our purpose was to determine the incidence of sebaceous hyperplasia in heart and kidney transplant recipients and its association with neoplasia.Methods: Patients undergoing heart transplantation from a single transplant center were examined during a 30-month screening period to establish the prevalence of cutaneous abnormalities. Results: Sixteen of 104 (16%) heart transplant recipients had sebaceous hyperplasia in comparison with 1% of an age- and sex-matched control group. Those with sebaceous hyperplasia did not have a significantly higher incidence of hypertrichosis than those without sebaceous hyperplasia.Conclusion: Sebaceous hyperplasia is seen in heart transplant recipients. It does not appear to be connected with hypertrichosis, in which it is believed that the pilosebaceous unit is the target of the direct effects of cyclosporine. We propose that the development of sebaceous hyperplasia is related to the process of dysplastic epithelial proliferation in transplant recipients.