Zinc oxide enriched peat influence Escherichia coli infection related diarrhea, growth rates, serum and tissue zinc levels in Norwegian piglets around weaning: five case herd trials.
Zinc oxide enriched peat influence Escherichia coli infection related diarrhea, growth rates, serum and tissue zinc levels in Norwegian piglets around weaning: five case herd trials.
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DOI：
10.1186/s40813-017-0060-7
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发表时间：
2017
影响因子：
3.4
通讯作者：
Framstad T
中科院分区：
文献类型：
--
作者：
Oropeza-Moe M;Grøntvedt CA;Phythian CJ;Sørum H;Fauske AK;Framstad T
氧化锌（ZnO），通常用于控制仔猪断奶后腹泻，已被强调为从环境角度来看的潜在问题。该田间试验的目的是检查添加到泥炭中的不同来源和水平的ZnO对平均日增重（ADG）、围栏中的粪便评分以及断奶前后的血清和组织锌（Zn）水平的影响，以减少环境影响而不损失ZnO对肠道健康和生长的有益作用。纳入了5个具有肠毒性大肠杆菌病挑战的病例牛群。仔猪进入研究年龄为三或五周。所有仔猪均接受含<150 mg Zn/kg全价饲料的市售饲料。四个处理组接受添加了A：未涂覆的ZnO、B：脂质微胶囊化的ZnO、C：仅商业泥炭或D：无泥炭的商业泥炭（农场2和3）。在农场1、2和3中，确定了粪便评分的显著给药效应（P < 0.05）。与治疗C（P < 0.05）和D（P < 0.01）相比，治疗A导致较低的粪便评分。在农场2和3，处理A和D之间的个体平均日增重（iADG）存在显著差异（P < 0.05）。接受处理B的仔猪的iADG与处理A无显著差异。2016年，欧洲药品管理局兽药产品委员会得出结论，氧化锌预防猪腹泻的好处并不超过对环境的风险。尚未确定减少锌在环境中积累的有效替代措施。我们的研究结果表明，泥炭添加低浓度的涂层和未涂层氧化锌影响肠道健康的断奶仔猪反映增强体重增加和腹泻的发生率降低。从“一个健康”的角度来看，这种预防方法无疑是一种有利的选择。它还将有助于减少养猪业中抗生素的使用，同时减少ZnO造成的环境后果。
Zinc oxide (ZnO), commonly used to control post-weaning diarrhea in piglets, has been highlighted as of potential concern from an environmental perspective. The aim of this field trial was to examine effects of different sources and levels of ZnO added to peat on average daily weight gain (ADG), fecal score in pens and serum and tissue zinc (Zn) levels around time of weaning in order to reduce the environmental impact without loss of the beneficial effect of ZnO on intestinal health and growth. Five case herds with enterotoxic colibacillosis challenges were included. The piglets entered the study aged three or five weeks. All piglets received a commercial diet containing <150 mg Zn/ per kg of complete feed. Four treatment groups received commercial peat added A: uncoated ZnO, B: lipid microencapsulated ZnO, C: solely commercial peat or D: no peat (Farms 2 and 3). At Farms 1, 2 and 3, a significant effect of treatment was identified for fecal score (P < 0.05). Treatment A led to lower fecal scores compared to treatments C (P < 0.05) and D (P < 0.01). At Farms 2 and 3, there was a significant difference in individual average daily weight gain (iADG) between treatment A and D (P < 0.05). The iADG of piglets receiving treatment B did not differ significantly from treatment A. In 2016, The European Medicines Agency’s Committee on Veterinary Medicinal Products concluded that the benefits of ZnO for the prevention of diarrhea in pigs do not outweigh the risks to the environment. Effective alternative measures to reduce the accumulation of Zn in the environment have not been identified. Our results imply that peat added low concentration of both coated and uncoated ZnO influences the gut health of weaned piglets reflected by enhanced weight gain and reduced occurrence of diarrhea. This preventive approach certainly represents a favourable alternative in the “One Health” perspective. It will also contribute to reduced antibiotic use in pig farming while diminishing the environmental consequences caused by ZnO.