Evidence from three cohort studies on the expression of MUC16 around the time of implantation suggests it is an inhibitor of implantation
Evidence from three cohort studies on the expression of MUC16 around the time of implantation suggests it is an inhibitor of implantation
复制标题
三项关于植入期间 MUC16 表达的队列研究的证据表明它是植入抑制剂
DOI：
10.1007/s10815-020-01764-z
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发表时间：
2020-05-02
影响因子：
3.1
通讯作者：
Zhang, Songying
中科院分区：
文献类型：
--
作者：
Liu, Liu;Wang, Yangyang;Zhang, Songying
PurposeTo examine the expression of MUC16 in the endometrium peri-implantation period in three different cohort studies.MethodsThis was a retrospective observational cohort study. A total of 245 participants were recruited in three separate cohort studies: (1) women with recurrent miscarriage (n= 50) and fertile controls (n= 29); (2) women who had high (n= 20) or normal (n= 20) progesterone on the day of hCG trigger in ovarian stimulation cycle for IVF; and (3) women who did (n= 95) or did not (n= 31) conceive following frozen embryo transfer in HRT cycles. All subjects had archived endometrial samples precisely taken on LH+7 in natural cycles, or hCG+6 in ovarian stimulation cycles, or P+5 in HRT cycles. TheH-score (median, range) of MUC16 in the luminal epithelium and glandular epithelium was determined by using immunohistochemistry.ResultsThe median (range) ofH-score of MUC16 in the luminal epithelium (1) in women with recurrent pregnancy loss was 23.7 (0–300), which was significantly (P< 0.05) lower than that of 118.4 (7.7–300) in fertile controls; (2) in women with elevated progesterone on the day of hCG administration (147.8, 18.0–230.1), significantly (P< 0.05) higher than that of women with normal progesterone (61.0, 2.3–205.3); (3) in women who conceived (23.1, 0–250.3), significantly (P< 0.001) lower than that in women who did not conceive (58.4, 0–300).ConclusionThe expression of MUC16 in all three cohort studies is consistent with it being an inhibitor of implantation.
