CCR4 Expression in Tumor-Infiltrating Regulatory T Cells in Patients with Squamous Cell Carcinoma of the Lung: A Prognostic Factor for Relapse and Survival
CCR4 Expression in Tumor-Infiltrating Regulatory T Cells in Patients with Squamous Cell Carcinoma of the Lung: A Prognostic Factor for Relapse and Survival
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DOI：
10.1080/07357907.2019.1582848
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发表时间：
2019-03-16
影响因子：
2.4
通讯作者：
Yamaguchi, Etsuro
中科院分区：
文献类型：
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作者：
Asai, Nobuhiro;Kubo, Akihito;Yamaguchi, Etsuro
为了阐明肿瘤浸润效应调节性T细胞（eTcl 4）在非小细胞肺癌（NSCLC）中的预后影响，通过免疫组织化学检测108例连续手术NSCLC肿瘤中的CCR 4和Foxp 3来评估eTcl 4。多变量分析显示，CCR 4（+）eTcR占总TcR的高比例（40%）是肺鳞状细胞癌（SqCC）无复发生存期（OR：6.54，95%置信区间：1.67-25.7，p= 0.007）和总生存期（OR：3.76，p= 0.037）的唯一独立风险因素。这些结果强调了切除的肺SqCC中肿瘤浸润性TcB平衡的预后重要性。
To clarify the prognostic impact of tumor-infiltrating effector regulatory T cells (eTregs) in non-small cell lung cancer (NSCLC), eTregs were evaluated by immunohistochemical detection of CCR4 and Foxp3 in 108 consecutive surgical NSCLC tumors. Multivariate analysis showed that a high ratio of CCR4(+) eTregs to total Tregs (40%) was the only independent risk factor for relapse-free survival (odds ratio [OR]: 6.54, 95% confidence interval: 1.67-25.7, p=.007) and overall survival (OR: 3.76, p=.037) in lung squamous cell carcinoma (SqCC). These results highlight the prognostic importance of the balance of tumor-infiltrating Tregs in resected lung SqCC.