Precision of Protein Thermometry
Precision of Protein Thermometry
复制标题
DOI：
10.1103/physrevlett.127.098102
复制
发表时间：
2021-08-26
影响因子：
8.6
通讯作者：
Mugler, Andrew
中科院分区：
文献类型：
--
作者：
Vennettilli, Michael;Saha, Soutick;Mugler, Andrew
温度传感是一种普遍存在的细胞行为，但人们对温度传感精度的基本限制知之甚少。与化学浓度传感不同，温度传感的精度不受温度场本身外部波动的限制。相反，我们发现精确度受到温度敏感蛋白质的内在拷贝数、周转率和结合动力学的限制。开发一个基于典型TLPA蛋白的模型，我们发现细胞可以估计温度在2%以内。我们将这一预测与细菌温度感应的活体数据进行了比较。
Temperature sensing is a ubiquitous cell behavior, but the fundamental limits to the precision of temperature sensing are poorly understood. Unlike in chemical concentration sensing, the precision of temperature sensing is not limited by extrinsic fluctuations in the temperature field itself. Instead, we find that precision is limited by the intrinsic copy number, turnover, and binding kinetics of temperaturesensitive proteins. Developing a model based on the canonical TlpA protein, we find that a cell can estimate temperature to within 2%. We compare this prediction with in vivo data on temperature sensing in bacteria.