Effect of Lactation on Postpartum Cardiac Function of Pregnancy-Associated Hypertensive Mice
Effect of Lactation on Postpartum Cardiac Function of Pregnancy-Associated Hypertensive Mice
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DOI：
10.1210/en.2012-1789
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发表时间：
2013-02-01
期刊：
影响因子：
4.8
通讯作者：
Fukamizu, Akiyoshi
中科院分区：
文献类型：
--
作者：
Murata, Kazuya;Saito, Chiaki;Fukamizu, Akiyoshi
先兆子痫是妊娠期间的严重并发症，最近的流行病学研究表明先兆子痫与产后期间的心脏病发病率和死亡率之间存在关联。虽然产后期心血管疾病的风险受哺乳的影响，但其在有先兆子痫病史的母亲心脏中的作用尚不清楚。在这项研究中，我们调查了产后心脏重构和功能的变化，妊娠相关性高血压（PAH）小鼠哺乳和不哺乳。PAH小鼠的收缩压在妊娠第19天（E19）升高，在产后期间，泌乳和非泌乳（NL）组均降至正常水平。组织学分析显示，在产后4周（4 W-PP），泌乳组和NL组在E19时PAH小鼠的心脏肥大和巨噬细胞浸润均得到改善，但仍存在明显的纤维化。在E19时PAH小鼠中促纤维化基因和促炎细胞因子的mRNA表达增加在4 W-PP时在泌乳和NL组中均显著降低。超声心动图分析发现PAH小鼠和C57 BL/6 J小鼠在E19时的短轴缩短分数无显著差异。另一方面，在4 W-PP，NL PAH小鼠显示正常的缩短分数，但哺乳期PAH小鼠与NL PAH小鼠相比，心脏收缩力显着降低。这些结果表明，在妊娠期间高血压引起的心脏重构改善产后期间，除了纤维化，而哺乳诱导心脏收缩功能障碍的小鼠与妊娠相关的高血压病史。（内分泌学154：597-602，2013）
Preeclampsia is a serious complication during pregnancy, and recent epidemiological studies indicate the association between preeclampsia and cardiac morbidity and mortality during the postpartum period. Although the risk of cardiovascular diseases in the postpartum period is affected by lactation, its role in maternal heart with a history of preeclampsia remains unclear. In this study, we investigated postpartum change in cardiac remodeling and function of pregnancy-associated hypertensive (PAH) mice with and without lactation. The systolic blood pressure was increased in PAH mice at day 19 of gestation (E19) and was reduced to normal levels in both lactating and nonlactating (NL) groups in the postpartum period. Histological analyses revealed that cardiac hypertrophy and macrophage infiltration in PAH mice at E19 were improved in both lactating and NL groups at 4 weeks postpartum (4W-PP), while marked fibrosis remained. Increased mRNA expression of profibrotic genes and proinflammatory cytokines in PAH mice at E19 was significantly reduced in both lactating and NL groups at 4W-PP. Echocardiographic analysis found no significant differences in fractional shortening between PAH mice and C57BL/6J mice at E19. On the other hand, at 4W-PP, NL PAH mice showed normal fractional shortening, but lactating PAH mice exhibited significant decreases in cardiac contractility compared with NL PAH mice. These results show that cardiac remodeling induced by hypertension during pregnancy are improved in the postpartum period except fibrosis, whereas lactation induces cardiac contractile dysfunction in mice with a history of pregnancy-associated hypertension. (Endocrinology 154: 597-602, 2013)