Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man.
Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man.
复制标题
从CD8+ T细胞免疫中逃脱的突变：HCV的进化，从黑猩猩到人。
DOI：
10.1084/jem.20050808
复制
发表时间：
2005-06-06
影响因子：
15.3
通讯作者：
Walker, Christopher M
中科院分区：
文献类型：
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作者：
Bowen, David G;Walker, Christopher M
丙型肝炎病毒（HCV）建立持久性的机制尚未完全了解。以前的黑猩猩和现在的人类研究表明，MHC I类限制性HCV表位内的突变可能有助于病毒逃避细胞毒性T淋巴细胞（CTL）反应。然而，关于逃逸突变在病毒持续存在中的作用以及在没有免疫选择压力的情况下它们的命运，有几个悬而未决的问题。
The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I–restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure.