Alterations of the lipid profile after 7.5 years of low-dose antioxidant supplementation in the SU.VI.MAX study
Alterations of the lipid profile after 7.5 years of low-dose antioxidant supplementation in the SU.VI.MAX study
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DOI：
10.1007/s11745-006-1391-3
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发表时间：
2005-04-01
期刊：
影响因子：
1.9
通讯作者：
Roussel, AM
中科院分区：
文献类型：
--
作者：
Hercberg, S;Bertrais, S;Roussel, AM
据报道，抗氧化微量营养素与改善血液状况有关，但结果并不一致。本研究的目的是评估补充抗氧化剂对SU.VI.MAX研究中成人参与者血脂谱变化的影响。法国成年人（n = 12，741：7，713名35-60岁的女性和5，028名45-60岁的男性）每天接受抗氧化剂补充剂（120 mg维生素C，30 mg维生素E，6 mg β-胡萝卜素，100 μ g硒和20 mg锌）或匹配的安慰剂。中位随访时间为7.5年。7.5年后，在调整基线总胆固醇水平和降脂药物后，没有观察到补充剂对男性或女性总胆固醇的影响。与接受安慰剂的女性相比，接受补充剂的女性高胆固醇血症（>= 6.5 mmol/L）的患病率有升高的趋势（P= 0.06）。在两种性别中，接受补充剂的组显示出比安慰剂组更高的平均血清TG浓度（男性P= 0.06;女性P= 0.05）。补充维生素D的男性高胆固醇血症（>= 2.3 mmol/L）的患病率也显著较高（P= 0.03），但女性中没有。我们的研究结果表明，长期每天补充低剂量的β-胡萝卜素，维生素C和E，硒和锌不会改善血脂，甚至可能对某些血脂产生不利影响，可能会增加女性患高脂血症的风险。
Antioxidant micronutrients have been reported to be associated with an improvement in the blood profile, but the results are not consistent. The aim of the present study was to assess the effects of antioxidant supplementation on changes in the serum lipid profile of adult participants in the SU.VI.MAX study. French adults (n = 12,741: 7,713 females aged 35-60 yr, and 5,028 males aged 45-60 yr) received daily antioxidant supplementation (120 mg vitamin C, 30 mg vitamin E, 6 mg beta-carotene, 100 mu g selenium, and 20 mg zinc) or a matching placebo. Median follow-up time was 7.5 yr. After 7.5 yr, no effect of supplementation on total cholesterol was observed in men or women after adjusting for baseline total cholesterol levels and lipid-lowering medications. The prevalence of hypercholesterolemia (>= 6.5 mmol/L) showed a trend toward being higher in women who received supplements compared with those who received the placebo (P= 0.06). In both sexes, the group receiving supplements exhibited higher mean serum TG concentrations than did the placebo group (P= 0.06 in men; P= 0.05 in women). The prevalence of hypertriglyceridemia (>= 2.3 mmol/L) was also significantly higher in men who received supplements (P= 0.03), but not in women. Our results suggest than long-term daily supplementation with low doses of beta-carotene, vitamins C and E, selenium, and zinc does not result in an improved lipid profile and could even adversely affect some blood lipids, possibly with a higher risk of hyperlipidemia in women.