Imaging optically induced neural activity in the brain.
Imaging optically induced neural activity in the brain.
复制标题
DOI：
10.1109/iembs.2010.5627920
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Jansen E
中科院分区：
文献类型：
--
作者：
Mahadevan-Jansen A;Cayce JM;Friedman R;Roe AW;Konrad PE;Hillman E;Jansen E
红外神经刺激(INS)具有良好的外周神经系统特点；然而，向中枢神经系统(CNS)的转化提出了一系列新的挑战，这要求我们考虑不同的解剖学、多种细胞类型以及与CNS结构相关的生理学。这项研究是我们首次尝试将INS翻译为体内刺激中枢神经系统并成像相关的反应。这项研究的结果表明，惯性导航系统产生的本征光学信号具有相似的大小和形状，与特征良好的机械刺激有关。这项工作的意义可能导致神经植入，允许单细胞刺激，使设计闭合环神经假体成为可能。
Infrared neural stimulation (INS) is well characterized for the peripheral nervous system; however, translation to the central nervous system (CNS) presents a new set of challenges which require us to consider different anatomy, multiple cell types, and the physiology associated with structures in the CNS. This study presents our first attempt to translate INS to in vivo stimulation of the CNS and to image the related response. The results from this study show that INS generates intrinsic optical signals of similar magnitude and shape associated with well characterized mechanical stimuli. The implications of this work could lead to neural implants which allows for single cell stimulation making it possible to design closed loop neural prosthetics.