Coagulation and Ablation of Biological Soft Tissue by Quantum Cascade Laser with Peak Wavelength of 5.7μm
Coagulation and Ablation of Biological Soft Tissue by Quantum Cascade Laser with Peak Wavelength of 5.7μm
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峰值波长5.7μm量子级联激光凝固消融生物软组织
DOI：
10.1142/s1793545814500291
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发表时间：
2014
影响因子：
2.5
通讯作者：
Kunio Awazu
中科院分区：
文献类型：
--
作者：
Keisuke Hashimura;Katsunori Ishii;Naota Akikusa;Tadataka Edamura;Harumasa Yoshida;Kunio Awazu
包含在生物组织中的诸如水、蛋白质和脂质的分子吸收中红外（MIR）光，这允许这种光用于激光外科治疗。酯类、酰胺类和水在5-7 μm波长范围内表现出强吸收带，但目前临床使用的激光器中还没有能在此范围内发射的激光器。因此，目前的研究集中在量子级联激光器（QCL），这是一种新型的半导体激光器，可以在MIR波长发射，最近已经实现了高输出功率。对峰值波长为5.7 μm的高功率QCL进行了评价，以用作消融生物软组织的激光手术刀。基于表面和横截面图像，将激光束与鸡胸组织的相互作用与传统的CO2激光进行了比较。发现QCL具有足够的功率消融软组织，其凝固、碳化和消融效果与CO2激光相似。QCL也诱导了相当的光热效应，因为它作为一个伪连续波激光器，由于其低的峰值功率。因此，QCL可以用作有效的激光手术刀，并且还通过靶向MIR区域中的特定吸收带提供微创治疗的可能性。
Molecules such as water, proteins and lipids that are contained in biological tissue absorb mid-infrared (MIR) light, which allows such light to be used in laser surgical treatment. Esters, amides and water exhibit strong absorption bands in the 5–7 μm wavelength range, but at present there are no lasers in clinical use that can emit in this range. Therefore, the present study focused on the quantum cascade laser (QCL), which is a new type of semiconductor laser that can emit at MIR wavelengths and has recently achieved high output power. A high-power QCL with a peak wavelength of 5.7 μm was evaluated for use as a laser scalpel for ablating biological soft tissue. The interaction of the laser beam with chicken breast tissue was compared to a conventional CO2laser, based on surface and cross-sectional images. The QCL was found to have sufficient power to ablate soft tissue, and its coagulation, carbonization and ablation effects were similar to those for the CO2laser. The QCL also induced comparable photothermal effects because it acted as a pseudo-continuous wave laser due to its low peak power. A QCL can therefore be used as an effective laser scalpel, and also offers the possibility of less invasive treatment by targeting specific absorption bands in the MIR region.