Sunscreen use, wearing clothes, and number of nevi in 6- to 7-year-old European children
Sunscreen use, wearing clothes, and number of nevi in 6- to 7-year-old European children
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DOI：
10.1093/jnci/90.24.1873
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发表时间：
1998-12-16
影响因子：
10.3
通讯作者：
Grivegnée, AR
中科院分区：
文献类型：
--
作者：
Autier, P;Doré, JF;Grivegnée, AR
背景：以前的流行病学研究表明，防晒霜的使用与黑色素瘤皮肤癌的风险增加有关。由于高痣（痣）计数在成人是一个强大的预测黑色素瘤，我们进行了一项研究，检查痣的数量在6至7岁的欧洲儿童，根据他们的防晒霜的使用，方法：全身和部位特异性计数痣2毫米或更大的631名儿童在他们的小学一年级在四个欧洲城市。独立地，父母被采访了关于阳光照射，防晒霜的使用，和他们的孩子的身体防晒。结果如下：在调整了阳光照射和宿主特征（例如，皮肤光型，眼睛颜色）后，使用最高水平防晒霜的躯干上高痣计数的相对风险为1.68（95%置信区间[CI] = 1.09-2.59），在阳光下穿着最高水平衣服的相对风险为0.59（95% CI = 0.36-0.97）。防晒系数对痣数量没有影响，尽管中位数为17.4，晒伤数量与痣数量无关。使用防晒霜的风险最高的是那些从未经历过晒伤的儿童。结论：在欧洲的白色儿童中，防晒霜的使用似乎与痣的发展有关，可能是因为它允许更长的阳光照射。穿衣服可能是防止痣增殖的有效方法，由于高痣计数是黑色素瘤的强预测因子，防晒霜的使用可能与黑色素瘤的发生有关，因为它可能鼓励娱乐性阳光暴露。
Background: Previous epidemiologic studies have suggested that sunscreen use is associated with an increased risk of melanoma skin cancer. Because high nevi (mole) count in adults is a strong predictor of melanoma, we conducted a study examining the number of nevi in 6- to 7-year-old European children, according to their sunscreen use, Methods: Whole-body and site-specific counts of nevi 2 mm or larger were performed in 631 children in their first year of primary school in four European cities. Independently, parents were interviewed regarding sun exposure, sunscreen use, and physical sun protection of their child. Results: After adjustment for sun exposure and host characteristics (e,g,, skin phototype, eye color), the relative risk for high nevus count on the trunk was 1.68 (95% confidence interval [CI] = 1.09-2.59) for the highest level of sunscreen use and 0.59 (95% CI = 0.36-0.97) for the highest level of wearing of clothes while in the sun. The sun protection factor had no effect on nevus counts despite a high median value of 17.4, Sunburn number was not associated with nevus count. The highest risk associated with sunscreen use was found among children who had never experienced sunburn. Conclusions: In white, European children, sunscreen use appears to be associated with development of nevi, probably because it allows longer sun exposures. Wearing clothes may be an effective way to prevent proliferation of nevi, Since a high nevus count is a strong predictor of melanoma, sunscreen use may be involved in melanoma occurrence because it may encourage recreational sun exposure.