Cloning and chromosome assignment of the human CDX2 gene
Cloning and chromosome assignment of the human CDX2 gene
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DOI：
10.1046/j.1469-1809.1997.6150393.x
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发表时间：
1997-09-01
影响因子：
1.9
通讯作者：
Edwards, YH
中科院分区：
文献类型：
--
作者：
Drummond, F;Putt, W;Edwards, YH
尾型同源盒基因Cdx2编码一种在肠道中表达的转录因子，该转录因子被认为在肠上皮细胞的增殖和分化中起重要作用。尾型同源盒基因Cdx2零突变杂合的小鼠除了与异常分割相关的骨骼问题外，还表现出结肠近端多发腺瘤性息肉。在人类结直肠癌中，CDX2和碳酸酐酶1（一种由CDX2调节的基因）的表达减少或缺失。CDX2突变可能是某些结直肠癌发生的主要原因。我们克隆了人类CDX2 cDNA，并报道了人类基因在13q12-13染色体上的核苷酸和蛋白质序列。
The caudal-type homeobox gene Cdx2 encodes a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. Mice heterozygous for null mutations in the caudal-type homeobox gene Cdx2 show multiple adenomatous polyps in the proximal colon in addition to skeletal problems associated with abnormal segmentation. In human colorectal cancer the expression of bath CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. It is possible that mutation of CDX2 is a primary event in the origin of some colorectal cancers. We have cloned human CDX2 cDNA and report here the nucleotide and protein sequences and assignment of the human gene to chromosome 13q12-13.