Tissue engineering of human bladder
Tissue engineering of human bladder
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DOI：
10.1093/bmb/ldr003
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发表时间：
2011-03-01
影响因子：
6.7
通讯作者：
Atala, Anthony
中科院分区：
文献类型：
--
作者：
Atala, Anthony
有一些条件的膀胱，可导致功能丧失。其中许多需要重建程序。然而，目前的技术可能导致许多并发症。在实验室中创建的功能等同的膀胱组织替代膀胱组织可以改善重建手术的结果。使用PubMed进行文献综述，以确定提供证据表明组织工程技术可能有助于开发当前膀胱重建方法的替代方法的研究。许多动物研究和临床经验表明，使用实验室产生的组织和新器官重建膀胱是可能的。可用于在实验室中产生功能等同的泌尿系统组织的材料，特别是具有排斥潜力的非自体细胞，具有许多技术限制。目前的研究表明，使用生物材料为基础的，膀胱形状的支架与自体尿路上皮细胞和平滑肌细胞接种是目前膀胱组织工程的最佳选择。进一步研究开发新的生物材料和细胞来源，以及从发育生物学、信号转导研究和伤口愈合反应研究中获得的信息将是有益的。
There are a number of conditions of the bladder that can lead to loss of function. Many of these require reconstructive procedures. However, current techniques may lead to a number of complications. Replacement of bladder tissues with functionally equivalent ones created in the laboratory could improve the outcome of reconstructive surgery. A review of the literature was conducted using PubMed to identify studies that provide evidence that tissue engineering techniques may be useful in the development of alternatives to current methods of bladder reconstruction. A number of animal studies and several clinical experiences show that it is possible to reconstruct the bladder using tissues and neo-organs produced in the laboratory. Materials that could be used to create functionally equivalent urologic tissues in the laboratory, especially non-autologous cells that have the potential to reject have many technical limitations. Current research suggests that the use of biomaterial-based, bladder-shaped scaffolds seeded with autologous urothelial and smooth muscle cells is currently the best option for bladder tissue engineering. Further research to develop novel biomaterials and cell sources, as well as information gained from developmental biology, signal transduction studies and studies of the wound healing response would be beneficial.