WASP, Tregs, and food allergies - rare disease provides insight into a common problem.
WASP, Tregs, and food allergies - rare disease provides insight into a common problem.
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WASP、Treg 和食物过敏——罕见疾病提供了对常见问题的深入了解。
DOI：
10.1172/jci90198
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Gudjonsson,JohannE
中科院分区：
文献类型：
--
作者：
Liang,Yun;Gudjonsson,JohannE
Dysregulation of the type 2 immune system presents with various manifestations, including allergic inflammation, and has emerged as an alarming public health issue. The pathological mechanisms that underlie T helper type 2 cell–driven (Th2-driven) allergic diseases remain unclear. In particular, it is not completely understood how type 2 immunity is restricted in inflammatory responses. In this issue of theJCI, Lexmond et al. use Wiskott-Aldrich syndrome as a model disease and establish that the Wiskott-Aldrich gene product (WASP) serves an essential role in T regulatory cells to contain Th2 effector cell differentiation and prevent allergic sensitization to dietary antigens.
